{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:49:12Z","timestamp":1791607752740,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170062"],"award-info":[{"award-number":["32170062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072629"],"award-info":[{"award-number":["82072629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["iMetaOmics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inflammatory bowel disease (IBD) is a chronic disorder linked to an increased risk of colorectal cancer (CRC) and is characterized by significant dysbiosis in the gut microbiota. The commensal bacterium\n                    <jats:italic>Parabacteroides goldsteinii<\/jats:italic>\n                    (\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    ) has shown potential in modulating host metabolism and inflammatory responses. In this study, we investigated the probiotic properties of\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    and its mechanism of action in IBD models, with a particular focus on bile acid metabolism and diet\u2010microbiota interactions. Fecal samples from patients with ulcerative colitis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914), Crohn's disease (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922), and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913) were analyzed to assess\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    relative abundance. In dextran sulfate sodium (DSS)\u2010induced colitis and azoxymethane (AOM)\/DSS\u2010induced CRC mouse models, administration of\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    significantly attenuated inflammation and tumorigenesis, particularly under fiber\u2010free diet conditions. Metabolomic profiling revealed an enrichment of secondary bile acids in\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    \u2010treated mice, suggesting a link between bile acid metabolism and its anti\u2010inflammatory effects. Further mechanistic studies using bile salt hydrolase inhibitors and\n                    <jats:italic>Tgr5<\/jats:italic>\n                    knockout mice confirmed the role of bile acid regulation in mediating the therapeutic benefits of\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    . Additionally, we found that dietary factors significantly influenced the colonization and metabolic activity of\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    , thereby modulating its probiotic efficacy. This highlights the potential for microbiome\u2010based therapies tailored to specific dietary contexts in the treatment of IBD. Our findings demonstrate that\n                    <jats:italic>P. goldsteinii<\/jats:italic>\n                    can modulate gut bile acid metabolism to alleviate colitis, making it a promising candidate for probiotic applications in IBD management, with dietary modulation enhancing its therapeutic potential.\n                  <\/jats:p>","DOI":"10.1002\/imo2.70008","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T05:46:27Z","timestamp":1742276787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interactions between\n                    <i>Parabacteroides goldsteinii<\/i>\n                    CCUG 48944 and diet ameliorate colitis in mice via regulating gut bile acid metabolism"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4917-9342","authenticated-orcid":false,"given":"Fujian","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiao","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of (Bio) Pharmaceutics Institute of Zhejiang University\u2010Quzhou Quzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-7397","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University Nanjing 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