{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:19:53Z","timestamp":1783970393150,"version":"3.55.0"},"reference-count":92,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["iMetaOmics"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Atractylodes lancea<\/jats:italic>\n                    , a traditional Chinese medicinal herb, is divided into two chemotypes based on the production of volatile bioactive compounds: the geo\u2010authentic Maoshan chemotype (MSA, rich in atractylon and atractylodin) and the non\u2010authentic Hubei chemotype (HBA, dominated by hinesol and \u03b2\u2010eudesmol). However, the mechanisms underlying the differentiation of these chemotypes remain poorly understood. By sequencing analysis of wild and cultivated\n                    <jats:italic>A. lancea<\/jats:italic>\n                    samples from multiple provinces in China, we revealed that the genetic divergence into Maoshan\u2010Dabie Mountains group (MA) and Qinling\u2010Taihang Mountains group (SA) was occurred along altitudinal and climatic gradients, but the chemotype was not solely genetically determined. Interestingly, both MA and SA genotypes in the MSA\u2010favorable or HBA\u2010conducive soil could develop into the MSA or the HBA chemotype, respectively, indicating a role of the soil microbiome. Critically, specific rhizosphere microbiomes were indicated as key mediators\u2010core in this process, including\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    in MSA formation and\n                    <jats:italic>Paenibacillus<\/jats:italic>\n                    in HBA formation. Shared endophytic core genera, such as\n                    <jats:italic>Rhodococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Ralstonia<\/jats:italic>\n                    ,\n                    <jats:italic>Sphingomonas<\/jats:italic>\n                    , and\n                    <jats:italic>Bradyrhizobium<\/jats:italic>\n                    , further contributed to this divergence through species\u2010level functional variation. Using piecewise structural equation modeling, we further confirmed that altitude, climate, and soil properties directly or indirectly influenced the chemotype formation via genotype\u2013microbiome interactions. Taken together, this study highlights the central role of soil and microbes in the chemotype differentiation of\n                    <jats:italic>A. lancea<\/jats:italic>\n                    and provides new insights into its underlying mechanisms. The regulatory role of microbes in the production of volatile bioactive compounds offers a theoretical foundation for the microbial breeding strategies to improve medicinal quality and clinical efficacy.\n                  <\/jats:p>","DOI":"10.1002\/imo2.70058","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:01:08Z","timestamp":1760072468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The combined influence of microbiome and soil environment contributes to the chemotype differentiation in\n                    <i>Atractylodes lancea<\/i>"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2271-4411","authenticated-orcid":false,"given":"Hongyang","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs, National Resource Center for Chinese Materia 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