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To address this gap, we established the MOMMY cohort (The MOther\u2010infant Microbiota transmission and its link to long terM health of babY), a large, prospective birth cohort uniquely designed to investigate maternal\u2010paternal\u2010infant microbiota transmission and its impact on child health within the understudied Chinese population. MOMMY aims to recruit 20,000 families from three geographically and economically diverse regions across China. This cohort prospectively follows pregnant mothers, fathers, and their infants, with children up to 7 years of age. Since September 2019, we have systematically collected a comprehensive repository of longitudinal biospecimens\u2014including maternal and infant stool, breast milk, cord blood, and parental blood\u2014stored in an accredited biobank. This is complemented by extensive data on environmental exposures, diet, and health outcomes gathered through validated questionnaires and physician assessments. The MOMMY cohort's unique value lies in its unprecedented scale, geographic diversity, and its integrative multi\u2010omics design, which will combine metagenomic, metabolomic, immunologic, and epigenetic data. By creating this unique resource, MOMMY will elucidate how early\u2010life microbial and molecular trajectories, shaped by genetic and environmental factors, influence child development and disease risk, thereby filling a critical gap in global microbiome research.<\/jats:p>","DOI":"10.1002\/imo2.70068","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:11:53Z","timestamp":1765005113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MOMMY study profile: An integrative early\u2010life multi\u2010omics cohort in China"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-3780","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"first","affiliation":[{"name":"Microbiota I\u2010Center (MagIC) Hong Kong SAR China"},{"name":"Department of Anaesthesia and Intensive Care, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Microbiota I\u2010Center (MagIC) Hong Kong SAR China"},{"name":"Department of Anaesthesia and Intensive Care, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilan","family":"Wang","sequence":"additional","affiliation":[{"name":"Microbiota I\u2010Center (MagIC) Hong Kong SAR China"},{"name":"Department of Anaesthesia and Intensive Care, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Yuet\u2010Ling","family":"Ching","sequence":"additional","affiliation":[{"name":"Microbiota I\u2010Center (MagIC) Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Hung","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecologist, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting Fan","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"Hong Kong Hub of Paediatric Excellence The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Yeung","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecologist, Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China"},{"name":"The Chinese University of Hong Kong \u2010 Baylor College of Medicine Joint Medical Centre Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K. 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