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However, the limited efficacy of commercial vaccines and the absence of approved antiviral drugs underscore the urgent need for novel strategies to combat IBV, particularly in the context of antibiotic\u2010free poultry production. Emerging evidence suggests that gut microbiota plays a crucial role in shaping host immunity and antiviral resilience. In this study, we demonstrated that gut microbiota composition is a key determinant of IBV resistance in chickens, as revealed through a fecal microbiota transplantation (FMT) model. Utilizing multi\u2010omics approaches, we conducted a comprehensive characterization of microbiomic, viromic, and metabolic differences among adult chickens, young chickens, and FMT\u2010treated young chickens for the first time, establishing a mechanistic link between gut microbiota and IBV resistance. Building on these insights, longitudinal microbiome profiling in a newly developed persistent IBV infection model identified\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    as the key bacterium conferring IBV resistance, with its administration improving survival rates from 30\u201335% to 90\u201395%. Additionally, two novel candidate probiotics,\n                    <jats:italic>Cloacibacillus porcorum<\/jats:italic>\n                    and\n                    <jats:italic>Neglecta timonensis<\/jats:italic>\n                    , exhibited moderate yet measurable protective effects. Mechanistic investigations revealed that\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    enhances \u03b3\u2010aminobutyric acid (GABA) production, which suppresses NF\u2010\u03baB\u2010driven inflammatory responses, reduces pro\u2010inflammatory cytokine levels, alleviates nephritis, and upregulates antiviral interferon expression, thereby fortifying host defenses against IBV infection. These findings provide a scientific foundation for deploying live biotherapeutic products as an intervention strategy against IBV and highlight the broader potential of gut microbiota modulation in mitigating infectious diseases and optimizing poultry health management.\n                  <\/jats:p>","DOI":"10.1002\/imo2.70086","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:18:34Z","timestamp":1773001114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Akkermansia muciniphila<\/i>\n                    enhances chicken resistance to infectious bronchitis virus by boosting GABA synthesis and suppressing the NF\u2010\u03baB inflammatory pathway"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-1954","authenticated-orcid":false,"given":"Ouyang","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanci","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixiang","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Geng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangli","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanpeng","family":"Kuang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"Du","sequence":"additional","affiliation":[{"name":"Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control Wens Foodstuff Group Co. 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