{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:45:19Z","timestamp":1790700319418,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["iMeta"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The vaginal microbiome plays an essential role in the reproductive health of human females. As infertility increases worldwide, understanding the roles that the vaginal microbiome may have in infertility and in vitro fertilization (IVF) treatment outcomes is critical. To determine the vaginal microbiome composition of 1411 individuals (1255 undergoing embryo transplantation) and their associations with reproductive outcomes, clinical and biochemical features are measured, and vaginal samples are 16S rRNA sequenced. Our results suggest that both too high and too low abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    is not beneficial for pregnancy; a moderate abundance is more beneficial. A moderate abundance of\n                    <jats:italic>Lactobacillus\u00a0crispatus<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus iners<\/jats:italic>\n                    (~80%) (with a pregnancy rate of I\u2010B: 54.35% and III\u2010B: 57.73%) is found beneficial for pregnancy outcomes compared with a higher abundance (&gt;90%) of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    (I\u2010A: 44.81% and III\u2010A: 51.06%, respectively). The community state type (CST) IV\u2010B (contains a high to moderate relative abundance of\n                    <jats:italic>Gardnerella\u00a0vaginalis<\/jats:italic>\n                    ) shows a similar pregnant ratio (48.09%) with I\u2010A and III\u2010A,\u00a0and the pregnant women in this CST have a higher abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    species. Metagenome analysis of 71 samples shows that nonpregnant women are detected with more antibiotic\u2010resistance genes, and Proteobacteria and Firmicutes are the main hosts. The inherent differences within and between women in different infertility groups suggest that vaginal microbes might be used to detect infertility and potentially improve IVF outcomes.\n                  <\/jats:p>","DOI":"10.1002\/imt2.185","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T01:43:20Z","timestamp":1710899000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Vaginal microbiota are associated with in vitro fertilization during female infertility"],"prefix":"10.1002","volume":"3","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[{"name":"Antibiotics Research and Re\u2010evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy Chengdu University Chengdu 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