{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:58:37Z","timestamp":1792292317330,"version":"4.4.0"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370429"],"award-info":[{"award-number":["82370429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300496"],"award-info":[{"award-number":["82300496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370432"],"award-info":[{"award-number":["82370432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92168117"],"award-info":[{"award-number":["92168117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["iMeta"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dysbiosis of the gut microbiota has been implicated in hypertension, and drug\u2013host\u2013microbiome interactions have drawn considerable attention. However, the influence of angiotensin receptor blocker (ARB)\u2010shaped\u00a0gut microbiota on the host is not fully understood. In this work, we assessed the alterations of blood pressure (BP),\u00a0vasculatures, and intestines following ARB\u2010modified gut microbiome treatment and evaluated the changes in the intestinal transcriptome and serum metabolome in hypertensive rats. Hypertensive patients with well\u2010controlled BP under ARB therapy were recruited as human donors, spontaneously hypertensive rats (SHRs)\u00a0receiving normal saline\u00a0or valsartan were considered animal donors, and SHRs were regarded as recipients. Histological and immunofluorescence staining was used to assess the aorta and small intestine, and 16S rRNA amplicon sequencing was performed to examine gut bacteria. Transcriptome and metabonomic analyses were conducted to determine the intestinal transcriptome and serum metabolome, respectively. Notably, ARB\u2010modified fecal microbiota transplantation (FMT),\u00a0results in marked decreases in systolic BP levels, collagen deposition and reactive oxygen species\u00a0accumulation in the vasculature, and alleviated intestinal structure impairments in SHRs. These changes were linked with the reconstruction of the gut microbiota in SHR recipients post\u2010FMT,\u00a0especially with a decreased abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Aggregatibacter<\/jats:italic>\n                    , and\n                    <jats:italic>Desulfovibrio<\/jats:italic>\n                    . Moreover, ARB\u2010treated microbes contributed to increased intestinal\n                    <jats:italic>Ciart<\/jats:italic>\n                    ,\n                    <jats:italic>Per1<\/jats:italic>\n                    ,\n                    <jats:italic>Per2<\/jats:italic>\n                    ,\n                    <jats:italic>Per3<\/jats:italic>\n                    , and\n                    <jats:italic>Cipc<\/jats:italic>\n                    gene levels and decreased\n                    <jats:italic>Nfil3<\/jats:italic>\n                    and\n                    <jats:italic>Arntl<\/jats:italic>\n                    expression were detected in response to ARB\u2010treated microbes. More importantly, circulating metabolites were dramatically reduced in ARB\u2010FMT rats, including 6beta\u2010Hydroxytestosterone and Thromboxane B2. In conclusion, ARB\u2010modified gut microbiota exerts protective roles in vascular remodeling and injury, metabolic abnormality and intestinal dysfunctions, suggesting a pivotal role in mitigating hypertension and providing insights into the cross\u2010talk between antihypertensive medicines and the gut microbiome.\n                  <\/jats:p>","DOI":"10.1002\/imt2.222","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T09:20:56Z","timestamp":1721294456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Intestinal microbiota by angiotensin receptor blocker therapy exerts protective effects against hypertensive damages"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5102-4315","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2606-2326","authenticated-orcid":false,"given":"Si\u2010Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9300-8371","authenticated-orcid":false,"given":"Kai\u2010Xin","family":"Yan","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-4332","authenticated-orcid":false,"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-5280","authenticated-orcid":false,"given":"Jie","family":"Jiao","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-6506","authenticated-orcid":false,"given":"Yi\u2010Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9171-7215","authenticated-orcid":false,"given":"Mu\u2010Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-0170","authenticated-orcid":false,"given":"Ying","family":"Dong","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-3515","authenticated-orcid":false,"given":"Jiu\u2010Chang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China"},{"name":"Department of Cardiology, Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.10.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)31919-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.117.032380"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0222-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.122.18878"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac121"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.122.19350"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24628"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2011.01845.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-511"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271634"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28052265"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.144924"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1854642"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.120.16154"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.07.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.034"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258211011342"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.861829"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122378"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.115.05315"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00422-19"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.019"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.309006"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14366"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05728-y"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02234-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.07.011"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02217-7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14965"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.121.18711"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.765482"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.09.005"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2136618"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1070223"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14598"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01500-13"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123699"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102115"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-017-1042-z"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0260-4"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154404"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190368"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7100399"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.115.05396"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-019-0280-4"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.104989"},{"key":"e_1_2_11_49_1","first-page":"109","article-title":"Urinary Thromboxane B2 in Hypertensive Patients","volume":"75","author":"Hornych A.","year":"1982","journal-title":"Archives des Maladies du Coeur et des Vaisseaux"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.25.1001"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174435"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245816"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.552188"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00014.2020"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518669"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.112.190892"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0148-8"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.122.19316"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2019.1695840"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032650"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.05.016"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051303"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-0955-9"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111706"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.10.320"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.032433"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-022-03161-5"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228705"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03527"}],"container-title":["iMeta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/imt2.222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/imt2.222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/imt2.222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:21:49Z","timestamp":1785435709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/imt2.222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/imt2.222"],"URL":"https:\/\/doi.org\/10.1002\/imt2.222","archive":["Portico"],"relation":{},"ISSN":["2770-5986","2770-596X"],"issn-type":[{"value":"2770-5986","type":"print"},{"value":"2770-596X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,18]]},"assertion":[{"value":"2024-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e222"}}