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However, this can be\u00a0observed in both IBD and colorectal cancer, which would confound the diagnostic\u00a0results. Thus, we first established a new model for predicting Crohn's disease (CD) with high precision according to gene characteristics based on single nucleotide variants (SNVs). Next, five gene markers belonging to two\u00a0species, <jats:italic>F. prausnitzii<\/jats:italic> and <jats:italic>Eubacterium rectale<\/jats:italic>, that were enriched in the CD group were obtained to build a CD prediction model, and high accuracy in distinguishing the CD and control groups was observed in the discovery (area under curve [AUC]\u2009=\u200991.13%) and validation cohorts (AUC\u2009=\u200979.55%). The model still maintained high accuracy after expanding the healthy cohort (AUC\u2009=\u200989.75%). High disease specificity in distinguishing CD and CRC groups (AUC\u2009=\u200995.74%) was also proven. This study establishes a novel diagnostic method for predicting IBD that also provides unprecedented insight for the early, painless diagnosis of other non\u2010communicable\u00a0diseases.<\/jats:p>","DOI":"10.1002\/imt2.40","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T06:20:00Z","timestamp":1658730000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Establishing a novel inflammatory bowel disease prediction model based on gene markers identified from single nucleotide variants of the intestinal microbiota"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-9200","authenticated-orcid":false,"given":"Shuaiming","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Hainan University  Haikou China"},{"name":"Key Laboratory of Food Nutrition and Functional Food of Hainan Province  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-3418","authenticated-orcid":false,"given":"Denghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Hainan University  Haikou China"},{"name":"Key Laboratory of Food Nutrition and Functional Food of Hainan Province  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanwei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Hainan University  Haikou China"},{"name":"Key Laboratory of Food Nutrition and Functional Food of Hainan Province  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Huang","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Hainan University  Haikou China"},{"name":"Key Laboratory of Food Nutrition and Functional Food of Hainan Province  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312135"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.04.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0306-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.441"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw070"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0646-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1869505"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080600"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(02)02722-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1868-7083-4-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1134082"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00479.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy258"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1237-9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2939"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7528"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319188"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0405-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3589"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr509"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","unstructured":"Cutler Adele D.Richard Cutler andJohnR. 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