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Beneficial and adverse effects of the Lachnospiraceae on host health were reported, but the diversities at species\/strain levels as well as their metabolites of Lachnospiraceae have been, so far, not well documented. In the present study, we report on the collection of 77\n                    <jats:italic>h<\/jats:italic>\n                    uman\u2010originated\n                    <jats:italic>L<\/jats:italic>\n                    a\n                    <jats:italic>ch<\/jats:italic>\n                    nospiraceae\n                    <jats:italic>sp<\/jats:italic>\n                    ecies (please refer hLchsp,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/hgmb.nmdc.cn\/subject\/lachnospiraceae\">https:\/\/hgmb.nmdc.cn\/subject\/lachnospiraceae<\/jats:ext-link>\n                    ) and the in vitro metabolite profiles of 110 Lachnospiraceae strains (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/hgmb.nmdc.cn\/subject\/lachnospiraceae\/metabolites\">https:\/\/hgmb.nmdc.cn\/subject\/lachnospiraceae\/metabolites<\/jats:ext-link>\n                    ). The Lachnospiraceae strains in hLchsp produced 242 metabolites of 17 categories. The larger categories were alcohols (89), ketones (35), pyrazines (29), short (C2\u2013C5), and long (C\u2009&gt;\u20095) chain acids (31), phenols (14), aldehydes (14), and other 30 compounds. Among them, 22 metabolites were aromatic compounds. The well\u2010known beneficial gut microbial metabolite, butyric acid, was generally produced by many Lachnospiraceae strains, and\n                    <jats:italic>Agathobacter rectalis<\/jats:italic>\n                    strain Lach\u2010101 and\n                    <jats:italic>Coprococcus comes<\/jats:italic>\n                    strain NSJ\u2010173 were the top 2 butyric acid producers, as 331.5 and 310.9\u2009mg\/L of butyric acids were produced in vitro, respectively. Further analysis of the publicly available cohort\u2010based volatile\u2010metabolomic data sets of human feces revealed that over 30% of the prevailing volatile metabolites were covered by Lachnospiraceae metabolites identified in this study. This study provides Lachnospiraceae strain resources together with their metabolic profiles for future studies on host\u2013microbe interactions and developments of novel probiotics or biotherapies.\n                  <\/jats:p>","DOI":"10.1002\/imt2.58","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T02:54:53Z","timestamp":1665716093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":208,"title":["Metabolite profiling of human\u2010originated Lachnospiraceae at the strain level"],"prefix":"10.1002","volume":"1","author":[{"given":"Rashidin","family":"Abdugheni","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Resources, Environmental Microbiology Research Center (EMRC) Institute of Microbiology, Chinese Academy of Sciences  Beijing China"},{"name":"State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography, Chinese Academy 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