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This review establishes a multidimensional framework by delineating the crosstalk between the gut microbiome and the host throughout the preconception, prenatal, postpartum, and early childhood stages. We first highlight the emerging paradigm of biparental microbial contributions during the preconception period, detailing how paternal and maternal niches jointly prime offspring development. Moving into pregnancy, we examine the maternal reservoir, integrating the role of gut microbiota\u2010derived metabolites across multiple trimesters in prenatal priming and vertical transmission. For the postpartum period, we discuss the development of the multikingdom gut microbiome and address the impacts of delivery modes and clinical interventions. Here, we articulate a critical knowledge gap: the discrepancy between taxonomic \u201ccatch\u2010up\u201d and true functional restoration, particularly in vulnerable cohorts such as preterm infants. Furthermore, we propose a \u201cdevelopmental synchronization\u201d model within the maternal\u2013infant\u2013microbiome continuum. This model posits that early\u2010life \u201cwindows of opportunity\u201d are defined by the obligate temporal coupling of host physiological maturation with stage\u2010specific microbial metabolic signals. From a translational perspective, we discuss how this framework informs the development of precision interventions, such as stage\u2010specific probiotics, prebiotics, or metabolic modulators. These therapies aim to restore not only the microbial composition but also the synchronized functional dialog between the microbiome and host development. By mapping the \u201cmicrobiota\u2013metabolite\u2013host target\u2013physiological phenotype\u201d network, we provide a systematic roadmap for precision\u2010targeted interventions during the first 1000 days of life.<\/jats:p>","DOI":"10.1002\/imt2.70151","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:58:22Z","timestamp":1785902302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal and infant gut microbiome"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9727-295X","authenticated-orcid":false,"given":"Huidi","family":"Wang","sequence":"first","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital Southern Medical University Guangzhou 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