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This study aimed to investigate the impact of Bazi Bushen Capsule (BZBS) on endometrial aging and its underlying mechanisms. Using naturally aged mice and\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose\u2010induced senescent human endometrial stromal cell lines, along with primary human endometrial stromal cells, we explored the effects of BZBS through single\u2010cell RNA sequencing, transcriptome analysis, network pharmacology, and molecular dynamics simulations. Our results showed that BZBS improved endometrial receptivity, and decidualization by activating the AMPK\u2212SIRT3 pathway. The key bioactive components of BZBS were identified as ginsenosides Rb1, Rb2, Rg5, and luteolin. Specifically, luteolin restored mitochondrial homeostasis by regulating PINK1\/Parkin\u2212mediated mitophagy and inhibiting Drp1. These findings suggested that BZBS effectively restored endometrial function and offered a promising therapeutic approach to counteract age\u2010related endometrial dysfunction, potentially improving fertility in women of advanced maternal age.\n                  <\/jats:p>","DOI":"10.1002\/imt2.70154","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:11:30Z","timestamp":1785312690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium"],"prefix":"10.1002","volume":"5","author":[{"given":"Shangqi","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing China"},{"name":"Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) Beijing China"},{"name":"National Clinical Key Specialty Construction Program, P. 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