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However, the precise roles of gut microbiota and microbial metabolism in this disease remain unclear. Through fecal metagenomic data mining and clinical cohort validation, we identified a gut bacterial strain with anti\u2010obesity potential,\n                    <jats:italic>Enterococcus faecium<\/jats:italic>\n                    (\n                    <jats:italic>E. faecium<\/jats:italic>\n                    ). It inhibited adipocyte enlargement, dyslipidemia, and hepatic steatosis in obese mice by metabolizing leucine to produce leucic acid (LEA). Colonization with\n                    <jats:italic>E. faecium<\/jats:italic>\n                    or exogenous LEA supplementation improved obesity\u2010associated metabolic phenotypes. Mechanistically,\n                    <jats:italic>E. faecium<\/jats:italic>\n                    metabolized leucine into LEA via putative branched\u2010chain amino acids metabolic enzymes. The bacterium\u2010derived LEA regulated mitochondrial oxidative phosphorylation and thus alleviated obesity. Furthermore, using a high\u2010content screening system and an in vitro fermentation model, we found that the dietary fiber glucomannan exerted anti\u2010obesity effects by promoting the growth of\n                    <jats:italic>E. faecium<\/jats:italic>\n                    . This study reveals the critical role of microbial metabolism and LEA production in ameliorating the onset and progression of obesity, providing a theoretical basis for dietary fiber intervention strategies targeting the gut microbiota.\n                  <\/jats:p>","DOI":"10.1002\/imt2.70173","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:29:26Z","timestamp":1790000966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut\n                    <i>Enterococcus faecium<\/i>\n                    derived leucic acid mediates the antiobesity effect of dietary fiber"],"prefix":"10.1002","author":[{"given":"Baifei","family":"Hu","sequence":"first","affiliation":[{"name":"College of Basic Medical Sciences; Key Laboratory of Chinese Medicinal Resource and Chinese Herbal Compound of the Ministry of Education Hubei University of Chinese Medicine Wuhan China"},{"name":"Hubei Shizhen 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