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The prevalence of MAFLD is rising by year\u00a0due to dietary changes, metabolic disorders, and no approved therapy, affecting a quarter of the global population and representing a\u00a0major economic problem that burdens healthcare systems. Currently, in addition to the common causative factors like insulin resistance, oxidative stress, and lipotoxicity, the role of immune cells, especially T cells, played in MAFLD is increasingly being emphasized by global scholars. Based on the diverse classification and pathophysiological effects of immune T cells, we comprehensively analyzed their bidirectional regulatory effects on the hepatic inflammatory microenvironment and MAFLD progression. This interaction between MAFLD and T cells was also associated with hepatic\u2010intestinal immune crosstalk and gut microbiota homeostasis. Moreover, we pointed out several T\u2010cell\u2010based therapeutic approaches including but not limited to adoptive transfer of T cells, fecal microbiota transplantation, and drug therapy, especially for natural products and Chinese herbal prescriptions. Overall, this study contributes to a better understanding of the important role of T cells played in MAFLD progression and corresponding therapeutic options and provides a potential reference for further drug development.<\/jats:p>","DOI":"10.1002\/imt2.76","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T09:15:41Z","timestamp":1674033341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Decoding the role of immune T cells: A new territory for improvement of metabolic\u2010associated fatty liver disease"],"prefix":"10.1002","volume":"2","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Sciences Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingning","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Life Sciences Beijing University of 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