{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:22:38Z","timestamp":1791051758356,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cadmium selenide (CdSe) quantum dots have gained increased attention for their potential use in biomedical applications. This has raised interest in assessing their toxicity. In this study, water\u2010soluble, cysteine\u2010capped CdSe nanocrystals with an average size of 15 nm were prepared through a one\u2010pot solution\u2010based method. The CdSe nanoparticles were synthesized in batches in which the concentration of the capping agent was varied with the aim of stabilizing the quantum dot core. The effects of the CdSe quantum dots on DNA stability, aggregation of blood platelets, and reducing activity of iron were evaluated <jats:italic>in vitro<\/jats:italic> . DNA damage was observed at a concentration of 200 \u03bcg\/mL of CdSe quantum dots. Furthermore, the CdSe nanocrystals exhibited high reducing power and chelating activity, suggesting that they may impair the function of haemoglobin by interacting with iron. In addition, the CdSe quantum dots promoted aggregation of blood platelets in a dose dependent manner. \u00a9 2012 IUBMB IUBMB Life, 64(12): 995\u20131002, 2012<\/jats:p>","DOI":"10.1002\/iub.1100","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T09:25:18Z","timestamp":1353921918000},"page":"995-1002","source":"Crossref","is-referenced-by-count":26,"title":["An <i>in vitro<\/i> assessment of the interaction of cadmium selenide quantum dots with DNA, iron, and blood platelets"],"prefix":"10.1002","volume":"64","author":[{"given":"Rekha","family":"Dunpall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeola Ayodeji","family":"Nejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanadha Srirama Rajasekhar","family":"Pullabhotla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy R.","family":"Opoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerish","family":"Revaprasadu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addmore","family":"Shonhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200703183"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200700595"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7339"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00743.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.5640\/insc.0104169"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2010.526227"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl0347334"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024406"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/etc.168"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/j100403a003"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrysgro.2008.03.032"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2009.10.008"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn204886b"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2004.07.005"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2496"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1822"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.5264\/eiyogakuzashi.44.307"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf00093a019"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-8-22"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706386"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.12.001"},{"key":"e_1_2_6_23_2","article-title":"Quantum dot cytotoxicity and ways to reduce it","author":"Winnik F. 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