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Also, drug metabolism, including phases I\u2013III and the drug\u2010responsive nuclear receptors, is controlled by the clock. Disturbances in circadian rhythm in humans can lead to pathologies, which is exemplified by increased cancer risk in long\u2010term shift workers. On the other hand, best tolerability of drugs with minimum side effects can be achieved if the timing of drug treatment is synchronized with the patients' individual clock. The aim of this review is to underline the importance of accepting the individuals' endogenous clock which can contribute to personalized, patient\u2010friendly optimization of drug therapies. \u00a9 2013 IUBMB Life, 65(6)487:\u2013496, 2013.<\/jats:p>","DOI":"10.1002\/iub.1160","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T18:13:01Z","timestamp":1365012781000},"page":"487-496","source":"Crossref","is-referenced-by-count":35,"title":["Circadian events in human diseases and in cytochrome P450\u2010related drug metabolism and therapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Rok","family":"Ko\u0161ir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemen","family":"\u0160paninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damjana","family":"Rozman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.022"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2747"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01225-4"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-257-1_1"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2106"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl207"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb925"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00825-5"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-003-0038-8"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00722-5"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.04.026"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00759-5"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx200538r"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.544251"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000193"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200401000-00001"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199602000-00002"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/15376511003690307"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.04.015"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-104-5-1266"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.10.6488"},{"key":"e_1_2_11_23_2","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1016\/S0021-9258(17)36679-6","article-title":"Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha\u2010hydroxylase P450 gene, CYP7. 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