{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T02:50:43Z","timestamp":1773629443567,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:00:00Z","timestamp":1378425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is manifested as an inflammatory polyarthritis. Authors aimed to analyze the relationship between serum hepcidin, 25 amino acid protein, concentration and the anemia profiles of RA and to estimate whether it could reflect the disease activity of RA. Also, this study was conducted to explore the linkage between interleukin\u20101 (IL\u20101) receptor antagonist gene (<jats:italic>IL\u20101RN<\/jats:italic>) polymorphism, proinflammatory cytokine, and RA. One hundred and eighty five RA patients were enrolled in the study. For all, the following criteria were measured: RA disease activities, anemia profiles, serum concentration of hepcidin using enzyme\u2010linked immunosorbent assay, and DNA samples were used to study genotypes of IL\u20101RN gene by polymerase chain reaction. Mean concentration of serum pro\u2010hepcidin was (93.6\u2009\u00b1\u200931.5 ng\/mL) in 185 RA patients. An increased frequency of the IL\u20101RN*1 and IL\u20101RN*2 alleles was relative to active RA (DAS28\u2009&gt;\u20095.1) than those with inactive to moderate RA (DAS28\u2009\u2264\u20095.1). Both hepcidin and <jats:italic>IL\u20101RN<\/jats:italic> gene showed significant correlation with each other as well with RA disease activity parameters and anemia profile. <jats:italic>IL\u20101RN<\/jats:italic> gene was significantly correlated with laboratory anemia profile apart from transferritin. There was a significant difference among pro\u2010hepcidin concentration and <jats:italic>IL\u20101RN<\/jats:italic> frequency regarding patients with anemia of chronic disease and those without. In conclusion, both serum concentration of pro\u2010hepcidin and <jats:italic>IL\u20101RN<\/jats:italic> genotypes frequency reflect the disease activity, regardless of the anemia states in RA patients, thus they may be another potential markers for disease activity of RA. \u00a9 2013 IUBMB Life, 65(10):883\u2010888, 2013<\/jats:p>","DOI":"10.1002\/iub.1205","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T03:09:48Z","timestamp":1378523388000},"page":"883-888","source":"Crossref","is-referenced-by-count":11,"title":["Interleukin\u20101 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity"],"prefix":"10.1002","volume":"65","author":[{"given":"Menha","family":"Swellam","sequence":"first","affiliation":[{"name":"Department of Biochemistry Genetic Engineering and Biotechnology Research Division National Research Center Dokki Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadiga M. Abu","family":"Gabal","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology Faculty of Medicine Beni\u2010Suef University, Beni\u2010Suef  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar Samir","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Microbial Biotechnology National Research Center Dokki Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.493406"},{"key":"e_1_2_6_3_1","first-page":"375","article-title":"Anemia of chronic disorders in systemic autoimmune diseases","volume":"82","author":"Bertero M. 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