{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:37:53Z","timestamp":1781005073415,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A novel type of venom peptide with six disulfide bridges, referred to as Androcin, was identified from the scorpion <jats:italic>Androctonus bicolor<\/jats:italic> using a cDNA library strategy. The amino acid sequence of Androncin displays little identity to other known peptides from scorpions. We found that the genomic sequence of Androcin consists of three exons interrupted by two introns that are localized in the signal sequence and mature peptide encoding regions, inserted in phase 2 and phase 0, respectively. This genomic organization is unique among those of the cysteine\u2010rich peptides from scorpions described so far. The primary and secondary structures of Androcin are homologous to those of the N\u2010terminal domains of insulin\u2010like growth factor\u2010binding proteins; this suggests that Androcin may block the normal function of IGFs. Toxicological analysis using the recombinant Androcin peptide revealed that Androcin is able to induce severe akinesia and anxiety\u2010like symptoms in mice. Androcin is a novel mammalian toxin with six disulfide bridges that provides the scorpion with another tool to subdue animals. \u00a9 2014 IUBMB Life, 66(4):277\u2013285, 2014<\/jats:p>","DOI":"10.1002\/iub.1261","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T14:23:47Z","timestamp":1399386227000},"page":"277-285","source":"Crossref","is-referenced-by-count":12,"title":["Androcin, a novel type of cysteine\u2010rich venom peptide from <i>Androctonus bicolor<\/i>, induces akinesia and anxiety\u2010like symptoms in mice"],"prefix":"10.1002","volume":"66","author":[{"given":"Ye","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biogeology and Environmental Geology &amp; Department of Biological Science and Technology School of Environmental Studies, China University of Geosciences (Wuhan) Wuhan 430074 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Chun","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biogeology and Environmental Geology &amp; Department of Biological Science and Technology School of Environmental Studies, China University of Geosciences (Wuhan) Wuhan 430074 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biogeology and Environmental Geology &amp; Department of Biological Science and Technology School of Environmental Studies, China University of Geosciences (Wuhan) Wuhan 430074 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Nie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biogeology and Environmental Geology &amp; Department of Biological Science and Technology School of Environmental Studies, China University of Geosciences (Wuhan) Wuhan 430074 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxia","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biogeology and Environmental Geology &amp; 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