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In addition, folate provides one\u2010carbon unit for methylation of a wide variety of biological substances including DNA, proteins, phospholipids, and neurotransmitters, thereby regulating their function. Recent epidemiological\u2010clinical and experimental studies suggest the association of folate deficiency with the risk of various cancers, birth defects, and cardiovascular diseases. Thus, it is important to consider the conditions that are associated with altered folate status and their consequences. The impairment in folate status has been found in number of pathophysiological conditions like inflammatory bowel disease, cancer, alcoholism, pregnancy, neonatal growth, and during administration of some drugs. The recent advances dealing with mechanistic aspects of impaired folate status in these conditions have been discussed in this review. \u00a9 2008 IUBMB IUBMB Life, 60(12): 834\u2013842, 2008<\/jats:p>","DOI":"10.1002\/iub.133","type":"journal-article","created":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T20:54:12Z","timestamp":1224622452000},"page":"834-842","source":"Crossref","is-referenced-by-count":47,"title":["Folate status in various pathophysiological conditions"],"prefix":"10.1002","volume":"60","author":[{"given":"Nissar Ahmad","family":"Wani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotdeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,21]]},"reference":[{"key":"e_1_2_10_2_2","first-page":"1","volume-title":"A folic acid metabolism in health and disease","author":"Stokstad E. 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