{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:52:29Z","timestamp":1792093949041,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation is a protective process for life that aims to restore body homeostasis by targeting the injury and by inducing repair mechanisms. This process can also become excessive and lead to chronic inflammation and organ fibrosis. Polyunsaturated fatty acids play a key role in inflammatory processes and their resolution. Indeed, numerous lipid mediators derived from n\u20103 or n\u20106 PUFA such as eicosanoids, endocannabinoids, or proresolving lipids are able to target transcription factors to modulate gene expression. One other important action mechanism is by modification of cell membrane composition. The purpose of the present review is to describe the potential mechanisms by which PUFA influence inflammatory processes. To illustrate this purpose, we focused on the interactions between PUFA and intestinal inflammation as an integrative example. \u00a9 2015 IUBMB Life, 67(9):659\u2013667, 2015<\/jats:p>","DOI":"10.1002\/iub.1428","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T14:53:41Z","timestamp":1443020021000},"page":"659-667","source":"Crossref","is-referenced-by-count":168,"title":["Polyunsaturated fatty acids and inflammation"],"prefix":"10.1002","volume":"67","author":[{"given":"Rachel","family":"Marion\u2010Letellier","sequence":"first","affiliation":[{"name":"INSERM Unit UMR1073, Rouen University and Rouen University Hospital 22, Boulevard Gambetta Rouen Cedex 76183 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Savoye","sequence":"additional","affiliation":[{"name":"INSERM Unit UMR1073, Rouen University and Rouen University Hospital 22, Boulevard Gambetta Rouen Cedex 76183 France"},{"name":"Department of Gastroenterology Rouen University Hospital 1 Rue De Germont Rouen Cedex 76031 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of Calgary  AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/0711-MR-311"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.006643"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2007.12.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.08.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2012.09.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076532"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.119768"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.05.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000177"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2014.10.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705822200"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3912"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409271102"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20109"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402166"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni745"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-175687"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","unstructured":"Hong S. Tian H. Lu Y. Laborde J. M. Muhale F. A. et al. (2014)Neuroprotectin\/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes.Am. J. Physiol. Cell Physiol.307 C1058\u2013C1067.","DOI":"10.1152\/ajpcell.00270.2014"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.06.017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-265363"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201272"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21122"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.09.007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603357200"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22380"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.06.001"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200361-JLR200"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.05.002"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2013.07.004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.164947"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3283479230"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2015.01.002"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.041"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2014-0022"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.132571"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601280103"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.10.008"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089605"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4318"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408384102"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2270"},{"key":"e_1_2_8_45_1","first-page":"215631","article-title":"15\u2010deoxy\u2010gamma 12,14\u2010prostaglandin J2 reduces liver impairment in a model of ConA\u2010induced acute hepatic inflammation by activation of PPAR gamma and reduction in NF\u2010kappa B activity","volume":"2014","author":"Chen K.","year":"2014","journal-title":"PPAR Res"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3318"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2561"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60750-8"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.007"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/63.5.741"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.063"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304119"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182810122"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.939"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.03.022"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.11.008"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.12.008"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.4.687"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.14.1690"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.196"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067791"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1011"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.01.012"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.06.033"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/917149"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073085"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132011"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.05.002"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1064OC"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-014-9788-x"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.1428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.1428","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.1428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:14:54Z","timestamp":1696356894000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.1428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":69,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/iub.1428"],"URL":"https:\/\/doi.org\/10.1002\/iub.1428","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}