{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:12:13Z","timestamp":1773418333773,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1002\/iub.1446","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T15:52:46Z","timestamp":1446047566000},"page":"934-942","source":"Crossref","is-referenced-by-count":6,"title":["Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis"],"prefix":"10.1002","volume":"67","author":[{"given":"Somia H.","family":"Abd-Allah","sequence":"first","affiliation":[{"name":"Medical Biochemistry Department; Faculty of Medicine, Zagazig University; Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal S.","family":"El-Shal","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department; Faculty of Medicine, Zagazig University; Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally M.","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department; Faculty of Medicine, Zagazig University; Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba F.","family":"Pasha","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department; Faculty of Medicine, Zagazig University; Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany M.","family":"Abou El-Saoud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine; Rheumatology and Rehabilitation Department; Zagazig University; Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar M.","family":"Abdel Galil","sequence":"additional","affiliation":[{"name":"Faculty of Medicine; Rheumatology and Rehabilitation Department; Zagazig University; Zagazig Egypt"},{"name":"Medicine Department; Faculty of Medicine, Umm Al-Qura University; Makkah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tysser A.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Internal Medicine Department; Medical Armed Academy; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"10.1002\/iub.1446-BIB0001|iub1446-cit-0001","doi-asserted-by":"crossref","first-page":"37.","DOI":"10.1186\/1546-0096-11-37","article-title":"Temporomandibular signs, symptoms, joint alterations and disease activity in juvenile idiopathic arthritis-an observational study","volume":"11","author":"Cedstr\u00f6mer","year":"2013","journal-title":"Pediatr. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0002|iub1446-cit-0002","first-page":"322","article-title":"Association between the ultrasonographic and clinical findings in the hips of patients with juvenile idiopathic arthritis","volume":"53","author":"Silva","year":"2013","journal-title":"Rev. Bras. Reumatol."},{"key":"10.1002\/iub.1446-BIB0003|iub1446-cit-0003","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5455\/apr.012420121458","article-title":"The IL-1 receptor antagonist gene polymorphism in Turkish patients with juvenile idiopathic arthritis","volume":"1","author":"Sozeri","year":"2012","journal-title":"Ann. Paediatr. Rheum."},{"key":"10.1002\/iub.1446-BIB0004|iub1446-cit-0004","doi-asserted-by":"crossref","first-page":"2.","DOI":"10.1186\/1546-0096-9-2","article-title":"Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis","volume":"9","author":"Kostik","year":"2011","journal-title":"Pediatr. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0005|iub1446-cit-0005","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.1446-BIB0006|iub1446-cit-0006","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/ncprheum0727","article-title":"Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?","volume":"4","author":"Murphy","year":"2008","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0007|iub1446-cit-0007","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/ard.2004.022434","article-title":"MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis","volume":"64","author":"Tchetverikov","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1002\/iub.1446-BIB0008|iub1446-cit-0008","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/ard.61.2.161","article-title":"Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment","volume":"61","author":"Ribbens","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"10.1002\/iub.1446-BIB0009|iub1446-cit-0009","first-page":"98","article-title":"Serum matrix metalloproteinase-3 as predictor of joint destruction in rheumatoid arthritis, treated with non-biological disease modifying anti-rheumatic drugs","volume":"56","author":"Mamehara","year":"2010","journal-title":"Kobe J. Med. Sci."},{"key":"10.1002\/iub.1446-BIB0010|iub1446-cit-0010","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10067-007-0701-3","article-title":"Elevated serum receptor activator of NF\u03baB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)\u22123, and ProMMP-1 in patients with juvenile idiopathic arthritis","volume":"27","author":"Sarma","year":"2008","journal-title":"Clin. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0011|iub1446-cit-0011","first-page":"251","article-title":"Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1) and MMP-1\/TIMP-1 complexes in rheumatic diseases: correlation with clinical activity of rheumatoid arthritis versus other surrogate markers","volume":"26","author":"Keyszer","year":"1999","journal-title":"J. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0012|iub1446-cit-0012","first-page":"1774","article-title":"Synovial membrane expression of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides","volume":"29","author":"Gattorno","year":"2002","journal-title":"J. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0013|iub1446-cit-0013","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/rheumatology\/kei025","article-title":"Levels of matrix metalloproteinase MMP1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study","volume":"44","author":"Peake","year":"2005","journal-title":"Rheumatology"},{"key":"10.1002\/iub.1446-BIB0014|iub1446-cit-0014","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00296-008-0805-3","article-title":"Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis","volume":"29","author":"Agarwal","year":"2009","journal-title":"Rheumatol. Int."},{"key":"10.1002\/iub.1446-BIB0015|iub1446-cit-0015","first-page":"5321","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription","volume":"58","author":"Rutter","year":"1998","journal-title":"Cancer Res."},{"key":"10.1002\/iub.1446-BIB0016|iub1446-cit-0016","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/gtmb.2011.0003","article-title":"Variation of matrix metalloproteinase 1 and 3 haplotypes and their serum levels in patients with rheumatoid arthritis and osteoarthritis","volume":"16","author":"Abd-Allah","year":"2012","journal-title":"Genet Test. Mol. Biomarkers"},{"key":"10.1002\/iub.1446-BIB0017|iub1446-cit-0017","doi-asserted-by":"crossref","first-page":"13055","DOI":"10.1074\/jbc.271.22.13055","article-title":"Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression","volume":"27","author":"Ye","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1002\/iub.1446-BIB0018|iub1446-cit-0018","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0019|iub1446-cit-0019","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/art.24516","article-title":"Development and validation of a composite disease activity score for juvenile idiopathic arthritis","volume":"61","author":"Consolaro","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1002\/iub.1446-BIB0020|iub1446-cit-0020","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ehj.2004.01.015","article-title":"Prognostic impact of matrix metalloproteinase gene polymorphism in patients with heart failure according to the etiology of left ventricular systolic dysfunction","volume":"25","author":"Gerad-Mizon","year":"2004","journal-title":"Eur. Heart J."},{"key":"10.1002\/iub.1446-BIB0021|iub1446-cit-0021","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/carcin\/bgh327","article-title":"Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China","volume":"26","author":"Fang","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1002\/iub.1446-BIB0022|iub1446-cit-0022","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1093\/bioinformatics\/bti643","article-title":"PAWE-3D: Visualizing power for association with error in case\/control genetic studies of complex traits","volume":"21","author":"Gordon","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1002\/iub.1446-BIB0023|iub1446-cit-0023","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s10067-013-2409-x","article-title":"Sleep and its relationship to pain, dysfunction, and disease activity in juvenile idiopathic arthritis","volume":"33","author":"Shyen","year":"2014","journal-title":"Clin. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0024|iub1446-cit-0024","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00296-013-2871-4","article-title":"Associates of school impairment in Egyptian patients with juvenile idiopathic arthritis: Sharkia Governorate","volume":"34","author":"Abdul-Sattar","year":"2014","journal-title":"Rheumatol. Int."},{"key":"10.1002\/iub.1446-BIB0025|iub1446-cit-0025","first-page":"771","article-title":"Induction of metalloproteinases expression by TLR ligands in human fibroblast like synoviocytes from juvenile idiopathic arthritis patients","volume":"13","author":"Agarwal","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"10.1002\/iub.1446-BIB0026|iub1446-cit-0026","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/gene.2011.46","article-title":"Influence of variations across the MMP-1 and \u22123 genes on the serum levels of MMP-1 and \u22123 and disease activity in rheumatoid arthritis","volume":"13","author":"Chen","year":"2012","journal-title":"Genes Immun."},{"key":"10.1002\/iub.1446-BIB0027|iub1446-cit-0027","first-page":"2241.","article-title":"Polymorphism in the matrix metalloproteinase-1 promoter gene and severity of rheumatoid arthritis","volume":"29","author":"Massarotti","year":"2002","journal-title":"J. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0028|iub1446-cit-0028","first-page":"235","article-title":"Functional polymorphisms in matrix metalloproteinase-1 and monocyte chemoattractant protein-1 and rheumatoid arthritis","volume":"32","author":"Lee","year":"2003","journal-title":"Scand. J. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0029|iub1446-cit-0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar1849","article-title":"Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study","volume":"8","author":"Rodriguez-Lopez","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1002\/iub.1446-BIB0030|iub1446-cit-0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00296-009-0974-8","article-title":"Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis","volume":"30","author":"Scherer","year":"2010","journal-title":"Rheumatol Int."},{"key":"10.1002\/iub.1446-BIB0031|iub1446-cit-0031","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/ar1164","article-title":"Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis","volume":"6","author":"D\u00f6rr","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1002\/iub.1446-BIB0032|iub1446-cit-0032","first-page":"826","article-title":"Serum and synovial fluid concentrations of matrix metalloproteinases 3 and its tissue inhibitor 1 in juvenile idiopathic arthritides","volume":"29","author":"Gottorno","year":"2002","journal-title":"J. Rheumatol."},{"key":"10.1002\/iub.1446-BIB0033|iub1446-cit-0033","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1442-200x.1999.01061.x","article-title":"Tissue inhibitor of metalloproteinases-1 and matrix metalloproteinase-3 in Japanese healthy children and in Kawasaki disease and their clinical usefulness in juvenile rheumatoid arthritis","volume":"41","author":"Matsuyama","year":"1999","journal-title":"Pediatr. Int."},{"key":"10.1002\/iub.1446-BIB0034|iub1446-cit-0034","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.gene.6364050","article-title":"Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis","volume":"5","author":"Mattey","year":"2004","journal-title":"Genes Immun."},{"key":"10.1002\/iub.1446-BIB0035|iub1446-cit-0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/rheumatology\/kem312","article-title":"Effect of matrix metalloproteinase-3 functional SNP on serum matrix metalloproteinase-3 level and outcome measures in Japanese RA patients","volume":"47","author":"Tsukahara","year":"2008","journal-title":"Rheumatology"},{"key":"10.1002\/iub.1446-BIB0036|iub1446-cit-0036","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/art.10972","article-title":"Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice","volume":"48","author":"Hooge","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1002\/iub.1446-BIB0037|iub1446-cit-0037","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/1529-0131(200004)43:4<852::AID-ANR16>3.0.CO;2-7","article-title":"Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis","volume":"43","author":"Yamanaka","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1002\/iub.1446-BIB0038|iub1446-cit-0038","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1136\/ard.62.11.1094","article-title":"Matrix metalloproteinases-3, \u22128, \u22129 as markers of disease activity and joint damage progression in early rheumatoid arthritis","volume":"62","author":"Tchetverikov","year":"2003","journal-title":"Ann Rheum. Dis."},{"key":"10.1002\/iub.1446-BIB0039|iub1446-cit-0039","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/rheumatology\/keg037","article-title":"Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis","volume":"42","author":"Green","year":"2003","journal-title":"Rheumatology"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.1446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.1446","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/iub.1446\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T21:13:14Z","timestamp":1625173994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iub.1446"}},"subtitle":["MMP-1 and MMP-3 Polymorphisms in JIA"],"short-title":[],"issued":{"date-parts":[[2015,10,28]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1002\/iub.1446","archive":["Portico"],"relation":{},"ISSN":["1521-6543"],"issn-type":[{"value":"1521-6543","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10,28]]}}}