{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:57:32Z","timestamp":1790704652655,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The poly(rC)\u2010binding protein 2 (<jats:italic>PCBP2<\/jats:italic>) is currently reported to inhibit cardiac hypertrophy. However, how PCBP2 is regulated at transcriptional level remains unknown. Here, we show that <jats:italic>Meis1<\/jats:italic>, a PBX1\u2010related homeobox gene, binds to PCBP2 promoter and promotes its transcription. In human failing heart tissues and murine hypertrophic heart tissues, the mRNA and protein levels of Meis1 are markedly downregulated, and the level of Meis1 significantly correlates with levels of <jats:italic>Nppa<\/jats:italic>, <jats:italic>Myh7<\/jats:italic>, and <jats:italic>PCBP2<\/jats:italic>. In neonatal rat cardiomyocytes, angiotensin II (Ang II) treatment induces hypertrophic growth of the cells (increase in cell size, enhanced protein synthesis, and hyperexpression of hypertrophic fetal genes), which are significantly inhibited by Meis1 overexpression or promoted by Meis1 knockdown. Meis1 also reduces Ang II\u2010induced activation of Akt\u2010mTOR pathway. Finally, we show that PCBP2 overexpression rescues the Meis1 effects of Akt\u2010mTOR pathway and hypertrophy of cardiomyocytes. \u00a9 2015 IUBMB Life, 68(1):13\u201322, 2016<\/jats:p>","DOI":"10.1002\/iub.1456","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T09:40:45Z","timestamp":1448358045000},"page":"13-22","source":"Crossref","is-referenced-by-count":15,"title":["<scp>Meis1<\/scp> promotes poly<scp> (rC)<\/scp>\u2010binding protein 2 expression and inhibits angiotensin <scp>II<\/scp>\u2010induced cardiomyocyte hypertrophy"],"prefix":"10.1002","volume":"68","author":[{"given":"Yunjiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60397-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.105"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838202024627"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.05.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.03.012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.06.139"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.10.032"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302023"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401578"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1602107"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12054"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2961"},{"key":"e_1_2_6_16_1","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a\u2010dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan N. R.","year":"2009","journal-title":"J. Clin. 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