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The physiological functions of Se are carried out by selenoproteins, in which Se is specifically incorporated as the amino acid, selenocysteine. Importantly, both beneficial and toxic effects of Se have been reported suggesting that the mode of action of Se is strictly chemical form and concentration dependent. Additionally, there is a relatively narrow window between Se deficiency and toxicity and growing evidence suggests that Se health effects depend greatly on the baseline level of this micronutrient. Thus, Se supplementation is not an easy task and requires an individualized approach. It is essential that we continue to explore and better characterize Se containing compounds and mechanisms of action, which could be crucial for disease prevention and treatment. \u00a9 2015 IUBMB Life, 68(2):97\u2013105, 2016<\/jats:p>","DOI":"10.1002\/iub.1466","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T03:26:51Z","timestamp":1451446011000},"page":"97-105","source":"Crossref","is-referenced-by-count":221,"title":["Biological activity of selenium: Revisited"],"prefix":"10.1002","volume":"68","author":[{"given":"Jagoda K.","family":"Wrobel","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Power","sequence":"additional","affiliation":[{"name":"Nutrigenomics Research Center, Alltech Nicholasville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Toborek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine Miami FL USA"},{"name":"Jerzy Kukuczka Academy of Physical Education Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60272a"},{"key":"e_1_2_8_3_1","first-page":"88","article-title":"Relation between selenium traces in L\u2010cystine and protection against dietary liver necrosis","volume":"8","author":"Schwarz K.","year":"1959","journal-title":"Metabolism"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3275"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00075-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.12.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3526"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4591"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6277"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0351"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2014.07.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.03.002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01854.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65500-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.4.762"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0544"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29071"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1310\/A7LC-7C9V-EWKF-2Y0H"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.07.017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7500-8_16"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601800"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2001.10719007"},{"key":"e_1_2_8_25_1","first-page":"239","article-title":"Selenium biochemistry and cancer: a review of the literature","volume":"9","author":"Patrick L.","year":"2004","journal-title":"Altern. 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