{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:25:29Z","timestamp":1761017129323},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,24]],"date-time":"2016-01-24T00:00:00Z","timestamp":1453593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370602","81400082"],"award-info":[{"award-number":["81370602","81400082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK2012573 and BK20140219"],"award-info":[{"award-number":["BK2012573 and BK20140219"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015M570479"],"award-info":[{"award-number":["2015M570479"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatic veno\u2010occlusive disease (HVOD), one serious complication following hematopoietic stem cell transplantation (HSCT), is mainly initiated by the damage to sinusoidal endothelial cells and hepatocytes. Long non\u2010coding RNAs (lncRNAs) play an important role in the proliferation of hepatocytes and liver regeneration. lncRNAs profile in hepatocytes post\u2010HSCT remains unclear. The aim of this study is to evaluate the profile of lncRNAs in hepatocytes of mice after HSCT. Mice HSCT model was established through infusion of 5 \u00d7 10<jats:sup>6<\/jats:sup> bone marrow mononuclear cells. On day 7, 14 and 33 after HSCT, mice were sacrificed for analysis of liver pathology, function and index. Total RNA was extracted from hepatocytes of mice on day 14 for microarray analysis of the expression profiles of lncRNAs by Arraystar Mouse lncRNA Microarray v2.0. Obvious edema and spotty necrosis of hepatocytes with inflammatory cells infiltration were observed post\u2010HSCT. Meanwhile, increased levels of alkaline phosphatase, aspartate transaminase, and total bilirubin, as well as elevated liver index were also found. 2,918 up\u2010regulated and 1,911 down\u2010regulated lncRNAs in hepatocytes were identified. Some of differentially expressed mRNAs had adjacent lncRNAs that were also significantly dysregulated, with the same dysregulation direction. T\u2010cell receptor (up\u2010regulation) and VEGF signaling pathway (down\u2010regulation) were identified as one of the most enriched pathways. Dysregulated lncRNAs might be involved in hepatocytes damage after HSCT, suggesting targeting them might be a novel approach in amelioration of hepatocytes damage. \u00a9 2016 IUBMB Life, 68(3):232\u2013241, 2016<\/jats:p>","DOI":"10.1002\/iub.1479","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T05:14:58Z","timestamp":1453698898000},"page":"232-241","source":"Crossref","is-referenced-by-count":11,"title":["Long non\u2010coding <scp>RNA<\/scp>s expression profiles in hepatocytes of mice after hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"68","author":[{"given":"Jianlin","family":"Qiao","sequence":"first","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"},{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haina","family":"Yao","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Chu","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulu","family":"Wu","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunming","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Depeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailin","family":"Xu","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"},{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical College Xuzhou China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Xuzhou Jiangsu Province China"},{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052638"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.657623"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Veno\u2010occlusive disease of the liver complicating bone marrow transplantation","volume":"13","author":"Baglin T. 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