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Behavioral changes were evaluated through sucrose preference test (SPT), open\u2010field test, forced swimming test, and tail suspension test (TST), suggesting that Umb (20 and 40 mg\/kg) could effectively improve depression symptoms. Oral glucose tolerance test and serum insulin indicated that Umb attributed to the control of blood glucose levels. The phosphorylation of insulin receptor, insulin receptor substrate (IRS)\u22121, glycogen synthase kinase\u20103\u03b2, PI3K, and Akt was increased in Umb (20 and 40 mg\/kg) treatment according to Western blot analysis. Taken together, the current results suggested the ameliorative effect of Umb against insulin resistance in the CUMS\u2010induced rats. \u00a9 2016 IUBMB Life, 68(5):403\u2013409, 2016<\/jats:p>","DOI":"10.1002\/iub.1496","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T20:46:36Z","timestamp":1459457196000},"page":"403-409","source":"Crossref","is-referenced-by-count":24,"title":["Umbelliferone attenuates unpredictable chronic mild stress induced\u2010insulin resistance in rats"],"prefix":"10.1002","volume":"68","author":[{"given":"Qiang","family":"Su","sequence":"first","affiliation":[{"name":"Center for Translational Systems Biology and Neuroscience School of Basic Biomedical Science, Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Tao","sequence":"additional","affiliation":[{"name":"Center for Translational Systems Biology and Neuroscience School of Basic Biomedical Science, Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanqing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University  Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Translational Systems Biology and Neuroscience School of Basic Biomedical Science, Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Translational Systems Biology and Neuroscience School of Basic Biomedical Science, Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Translational Systems Biology and Neuroscience School of Basic Biomedical Science, Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.12.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/070674370805300702","article-title":"Major depression prevalence is very high, but the syndrome is a poor proxy for community populations\u2019 clinical treatment needs","volume":"53","author":"Patten S.","journal-title":"Can. 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