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The content of proinflammatory cytokines such as tumor necrosis factor\u2010alpha, interleukin\u20101 beta and interleukin\u20106 were detected. Besides, canonical nuclear factor kappa B (NF\u2010\u03baB) pathway was also assessed to evaluate the antiarthritic potential of sinomenine. Pathological sections of rat paws showed sinomenine and diclofenac sodium significantly alleviated articular cartilage lesion, cellular infiltration, epithelial cell degeneration, synovial tissue vasodilation and congestion. The phosphorylations of inhibitor of kappaB alpha and NF\u2010\u03baB subunit p65 were downregulated with the treatment of sinomenine in dose dependent manners, as well as proinflammatory cytokines. Therefore, it was assumed that sinomenine might be a new therapeutic candidate to treat arthritis. \u00a9 2016 IUBMB Life, 68(6):429\u2013435, 2016<\/jats:p>","DOI":"10.1002\/iub.1499","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T07:54:40Z","timestamp":1460706880000},"page":"429-435","source":"Crossref","is-referenced-by-count":27,"title":["Role of Sinomenine on Complete Freund's Adjuvant\u2010Induced Arthritis in Rats"],"prefix":"10.1002","volume":"68","author":[{"given":"Zhou","family":"Lan","sequence":"first","affiliation":[{"name":"School of Pharmacy Hubei University of Chinese Medicine Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hubei University of Chinese Medicine Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lvyi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy South\u2010Central University for Nationalities Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjing","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Hubei University of Chinese Medicine Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Hubei University of Chinese Medicine Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hubei University of Chinese Medicine Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.04.021"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.12.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.04.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.10.027"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.01.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476910601115184"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.04.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0159-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098560"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-005-2892-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.05.048"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.12.051"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.07.030"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.04.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.01.014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.05.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.06.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00243.2010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/82183"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-121699"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.06.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.10.031"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.01.005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.12.016"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230721"},{"key":"e_1_2_6_27_1","article-title":"Suppressing receptor\u2010interacting protein 140: a new sight for salidroside to treat cerebral ischemia","author":"Chen T.","year":"2015","journal-title":"Mol. 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