{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:48:35Z","timestamp":1793724515121,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific and Technological Research Council of Turkey (TUBITAK)","award":["3501\/113S431"],"award-info":[{"award-number":["3501\/113S431"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obesity is a major contributory factor of morbidity and mortality. It has been suggested that biological systems may be involved in the tendency to be and to remain physically inactive also behaviors such as food and beverage preferences and nutrient intake may at least partially genetically determined. Consequently, besides environment, genetic factors may also contribute to the level of physical activity and eating behaviors thus effect obesity. Therefore the aim of this study is to investigate the effect of various gene mutations on obesity, physical activity levels and eating behavior phenotypes. One hundred patients and 100 controls were enrolled to the study. Physical activity levels were measured with an actical acceloremeter device. Eating behaviors were evaluated using Three\u2010Factor Eating questionnaire (TFEQ). Associations between eating behavior scores and physical characteristics were also evaluated. The information about other obesity risk factors were also collected. Mutations were investigated with PCR, direct sequencing and Real\u2010Time PCR. rs1051168, rs8050146 \u22122778C\u2009&gt;\u2009T mutations were found statistically significant in patients, rs1121980 was found statistically significant in controls. 21 mutations were found in <jats:italic>MC4R<\/jats:italic> and near <jats:italic>MC4R<\/jats:italic> of which 18 of them are novel and 8 of them cause amino acid change. In addition, it was found that, some obesity related factors and questions of TFEQ are associated with various investigated gene mutations. Any relation between gene mutations and physical activity levels were not detected. It is thought that, due to the genotype data and eating behaviors, it may be possible to recommend patients for proper eating patterns to prevent obesity. \u00a9 2016 IUBMB Life, 68(10):806\u2013816, 2016<\/jats:p>","DOI":"10.1002\/iub.1558","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T03:03:52Z","timestamp":1473995032000},"page":"806-816","source":"Crossref","is-referenced-by-count":17,"title":["Effects of <i>MC4R<\/i>, <i>FTO,<\/i> and <i>NMB<\/i> gene variants to obesity, physical activity, and eating behavior phenotypes"],"prefix":"10.1002","volume":"68","author":[{"given":"Deniz","family":"Kirac","sequence":"first","affiliation":[{"name":"Department of Medical Biology Yeditepe University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Kasimay Cakir","sequence":"additional","affiliation":[{"name":"Department of Physiology Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Avcilar","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguzhan","family":"Deyneli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hizir","family":"Kurtel","sequence":"additional","affiliation":[{"name":"Department of Physiology Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Cigdem","family":"Kaspar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yeditepe University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurgul","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Ilter","family":"Guney","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000445"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2010.29"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn242"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-010-9412-7"},{"key":"e_1_2_6_6_1","first-page":"234","article-title":"Prevalence of Melanocortin Receptor 4 (MC4R) V103I Gene Variant and Its Association with Obesity among the Kampar Health Clinic Cohort, Perak, Malaysia","volume":"67","author":"Chua H. 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