{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:55:58Z","timestamp":1790232958334,"version":"4.1.0"},"reference-count":131,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["MOP-86514"],"award-info":[{"award-number":["MOP-86514"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iron is an essential nutrient that is potentially toxic due to its redox reactivity. Insufficient iron supply to erythroid cells, the major iron consumers in the body, leads to various forms of anemia. On the other hand, iron overload (hemochromatosis) is associated with tissue damage and diseases of liver, pancreas, and heart. Physiological iron balance is tightly controlled at the cellular and systemic level by iron regulatory proteins (IRP1, IRP2) and the iron regulatory hormone hepcidin, respectively. Underlying mechanisms often intersect to achieve optimal iron utilization, to control immune responses, and to prevent iron toxicity. This review focuses on systemic iron homeostasis in the context of erythropoiesis, a highly iron\u2010demanding process. We discuss the function and regulation of hepcidin by various stimuli, and highlight hepcidin\u2010dependent and \u2010independent mechanisms that link iron utilization with maturation of erythroid progenitor cells. \u00a9 2017 IUBMB Life, 69(6):399\u2013413, 2017<\/jats:p>","DOI":"10.1002\/iub.1629","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T02:46:42Z","timestamp":1491533202000},"page":"399-413","source":"Crossref","is-referenced-by-count":105,"title":["Systemic iron homeostasis and erythropoiesis"],"prefix":"10.1002","volume":"69","author":[{"given":"George","family":"Papanikolaou","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics School of Health Science and Education, Harokopion University Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Pantopoulos","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research and Department of Medicine McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.021"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.10.013"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2013"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408399209527576"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00348.2013"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5072289"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-272138"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13148"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25746"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.6.1697.1697"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00003"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.1.1"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04512"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-068148"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/7727"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-548305"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2015.09.003"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.065"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10308"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101825"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103786"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1222"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00176"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.12.031"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38499"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.12.012"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.007"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.08.003"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.02.026"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4703"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1365"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-041830"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1809"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-127480"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.370437"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008922200"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008923200"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57693"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-550467"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150014"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3863"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42011"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-337212"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13020"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151179498"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072632499"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1053"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1274"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12602-5"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3042"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-072610-145117"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.002"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.130"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000236"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041809"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3505"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-595256"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00160"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1777"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3016"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.335"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.320"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-721571"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348698"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.09.012"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-287292"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28254"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-729822"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.014"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.028"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24547"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1253-7"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-552281"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1472"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81151-4"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.016"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2481"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2477"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.01.010"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077267"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23173"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.057"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23198"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24178"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24359"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.003541"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.018"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-033969"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027631"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.650150"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-480095"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-411470"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38702"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1747"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-748541"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.689190"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-639112"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013136"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215686"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4844"},{"key":"e_1_2_16_104_1","first-page":"809","article-title":"The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major","volume":"91","author":"Kattamis A.","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-028787"},{"key":"e_1_2_16_106_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.33549\/physiolres.930841","article-title":"Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis","volume":"55","author":"Vokurka M.","year":"2006","journal-title":"Physiol. Res."},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1629"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0751-5"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-165738"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195503"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.069807"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2996"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-681494"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.336834"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-658419"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171054"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.01.026"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041260221"},{"key":"e_1_2_16_119_1","first-page":"288","article-title":"Serum transferrin receptor concentration and its ratio to bone marrow erythroblasts in iron deficiency anemia and anemia of chronic diseases","volume":"37","author":"Choi J. W.","year":"2007","journal-title":"Ann. Clin. Lab. Sci."},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-492454"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.016"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.007"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-315218"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68487"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-251496"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2015.09.007"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281360"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.118521"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24417"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-596254"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-617571"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12505"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.1629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.1629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iub.1629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.1629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:25:27Z","timestamp":1694003127000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.1629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":131,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/iub.1629"],"URL":"https:\/\/doi.org\/10.1002\/iub.1629","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}