{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:24:24Z","timestamp":1760909064077,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004686","name":"Deanship of Scientific Research, King Faisal University","doi-asserted-by":"publisher","award":["G\u2010528\u2010141\u201036"],"award-info":[{"award-number":["G\u2010528\u2010141\u201036"]}],"id":[{"id":"10.13039\/501100004686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin\u201010 (IL\u201010) is an anti inflammatory cytokine involved in the ongoing coronary inflammation and related patho\u2010physiological processes. The piece of work presented herein is aimed at investigating possible association of polymorphisms in IL\u201010 promoter with Saudi cardiovascular disease (CVD) patients. The study included 80 confirmed CVD patients with diabetes and 75 healthy control individuals both men and women. Concentration of IL\u201010 in the serum samples were measured by ELISA method. For single nucleotide polymorphism (SNP) analysis, Sanger method of DNA sequencing was followed. The IL\u201010 level was found to be significantly elevated in CVD patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and its associated complications viz. ST\u2010elevation myocardial infarction [STEMI] (<jats:italic>P<\/jats:italic> &lt;0.01), non ST\u2010elevation myocardial infarction [NSTEMI] (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and unstable angina [UA] (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). We also observed a significant association between polymorphisms in IL\u201010 promoter at \u22121082 and \u2212819 locus with Saudi CVD patients. Moreover, at \u22121082 A\/G locus, AA haplotype was found to be less frequent in the CVD patients compared with control individuals. On the other hand, highly significant rise in heterozygous (A\/G genotype) condition was observed in patient samples compared with control ones (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Similarly, the genotypic frequencies at \u2212819 C\/T locus were also found to be significantly associated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with CVD patients compared with control individuals. Our study provides the status of polymorphism in IL\u201010 promoter and its association with CVD risk in Saudi population. As per our information, ours is the first article that shows the genetic diversity in IL\u201010 promoters and its level in the Saudi CVD patients. \u00a9 2017 IUBMB Life, 69(7):522\u2013527, 2017<\/jats:p>","DOI":"10.1002\/iub.1637","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T05:46:44Z","timestamp":1493963204000},"page":"522-527","source":"Crossref","is-referenced-by-count":20,"title":["A putative association of interleukin\u201010 promoter polymorphisms with cardiovascular disease"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-415X","authenticated-orcid":false,"given":"Shams","family":"Tabrez","sequence":"first","affiliation":[{"name":"King Fahd Medical Research Center, King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murtaza","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biosciences Jamia Millia Islamia New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasimudeen R.","family":"Jabir","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center, King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelapram K.","family":"Firoz","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center, King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam Md.","family":"Ashraf","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center, King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"Hindawi","sequence":"additional","affiliation":[{"name":"Department of Hematology Faculty of Medicine, King Abdulaziz University Hospital Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazi A.","family":"Damanhouri","sequence":"additional","affiliation":[{"name":"King Fahd Medical Research Center, King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Nabil Alama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine, King Abdulaziz University Hospital Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1390"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666151209153823"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2008.12.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.3.611"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.09.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.231795"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00678-06"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00046405"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2011.01072.x"},{"key":"e_1_2_8_11_1","first-page":"282","article-title":"Association of polymorphisms G(\u2010174)C in IL\u20106 gene and G(\u20101082)A in IL\u201010 gene with traditional cardiovascular risk factors in patients with coronary artery disease","volume":"51","author":"Elsaid A.","year":"2014","journal-title":"Indian J. Biochem. Biophys."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr15047823"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.995"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00467-1"},{"key":"e_1_2_8_15_1","first-page":"159","article-title":"Influence of IL\u201010 polymorphism on the development of coronary artery disease in Pakistan","volume":"6","author":"Afzal M. S.","year":"2017","journal-title":"Asian Biomed."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22092"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25870"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2000"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.20.2579"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1525"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dcS13-2018"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.07.015"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25958"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00287-X"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200702000415"},{"key":"e_1_2_8_26_1","first-page":"1279","article-title":"Serum levels of interleukin\u20106, interleukin\u201010 and C\u2010reactive protein in relation to left ventricular function in patients with myocardial infarction treated with primary angioplasty","volume":"66","author":"Karpi\u0144ski L.","year":"2008","journal-title":"Kardiologia Polska"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01816.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03097-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3201.094973"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.06.033"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl058"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065232.57371.25"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.119271"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.02.040"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2017.1306866"},{"key":"e_1_2_8_36_1","first-page":"7937","article-title":"Study on the association between IL\u20101\u03b2, IL\u20108 and IL\u201010 gene polymorphisms and risk of coronary artery disease","volume":"8","author":"Ren B.","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"e_1_2_8_37_1","first-page":"17842","article-title":"Association between three interleukin\u201010 gene polymorphisms and coronary artery disease risk: a meta\u2010analysis","volume":"8","author":"Wang B.\u2010J.","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00754.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.019885"},{"key":"e_1_2_8_40_1","first-page":"136","article-title":"Functional interleukin\u201010 promoter variants in coronary artery disease patients in Tunisia","volume":"21","author":"Ben\u2010Hadj\u2010Khalifa S.","year":"2010","journal-title":"Eur. Cytokine Netw."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.06.025"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32831286e8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.06.032"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40142-013-0028-0"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.1637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.1637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:10:20Z","timestamp":1696392620000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.1637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,5]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/iub.1637"],"URL":"https:\/\/doi.org\/10.1002\/iub.1637","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"type":"print","value":"1521-6543"},{"type":"electronic","value":"1521-6551"}],"subject":[],"published":{"date-parts":[[2017,5,5]]}}}