{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:12:50Z","timestamp":1791645170563,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b2\u2010Cell dedifferentiation, characterized by loss of glucose sensitivity (\u03b2\u2010cell glucose sensitivity [\u03b2CGS]), has been reported to play an important role in the development of type 2 diabetes (T2D). Traditionally, \u03b2CGS was derived from C\u2010peptide\u2010based method. However, C\u2010peptide was not routinely examined in normal subjects and diabetes never treated with insulin. Thus, the aim of the study was to evaluate the use of insulin in oral glucose tolerance test (OGTT) in estimation of \u03b2\u2010cell glucose response ability. A total of 1,599 subjects including normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and T2D were included in the study. A subgroup of NGT subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a0591) were followed up for an average duration of 56.88\u2009\u00b1\u200920.76 months. Insulin release rate (IRR<jats:sub>INS<\/jats:sub>) in the function of glucose (IRR<jats:sub>INS<\/jats:sub> response to glucose [IRRG]) during OGTT was compared with \u03b2CGS. Both \u03b2CGS derived from C\u2010peptide by deconvolution approach and IRRG by insulin release progressively declined from NGT to IGT and T2D. Both \u03b2CGS and IRRG were associated with deposit of first\u2010phase insulin secretion (DI<jats:sub>1st<\/jats:sub>). After 56.88\u2009\u00b1\u200920.76 months, 32 (5.41%) NGT subjects had developed T2D. NGT subjects who progressed to diabetes after follow\u2010up had lower IRRG and DI<jats:sub>1st<\/jats:sub> levels than those who did not (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Furthermore, multiple logistic regression analyses showed that decreased IRRG was a significant independent risk predictor for future diabetes after adjustment of age, body mass index (BMI), homeostasis model assessment (HOMA)\u2010insulin resistance, DI<jats:sub>1st<\/jats:sub> and family history. NGT subjects with decreased IRRG during OGTT had defective early insulin secretion and were at higher risk of developing diabetes. IRRG could be a useful T2D predictor in NGT subjects. \u00a9 2017 IUBMB Life, 69(9):756\u2013766, 2017<\/jats:p>","DOI":"10.1002\/iub.1657","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T04:49:06Z","timestamp":1501562946000},"page":"756-766","source":"Crossref","is-referenced-by-count":5,"title":["Deterioration of insulin release rate response to glucose during oral glucose tolerance test is associated with an increased risk of incident diabetes in normal glucose tolerance subjects"],"prefix":"10.1002","volume":"69","author":[{"given":"Yuanyuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"},{"name":"Shanghai Key Laboratory of Diabetes Mellitus Shanghai People's Republic of China"},{"name":"Shanghai Diabetes Institute, Shanghai Jiao Tong University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"He","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics Central South University  Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Electronics and Information Engineering Tongji University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fuwai Hospital, Chinese Academy of Medical Sciences Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics Central South University  Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-7495","authenticated-orcid":false,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"},{"name":"Shanghai Key Laboratory of Diabetes Mellitus Shanghai People's Republic of China"},{"name":"Shanghai Diabetes Institute, Shanghai Jiao Tong University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"},{"name":"Shanghai Key Laboratory of Diabetes Mellitus Shanghai People's Republic of China"},{"name":"Shanghai Diabetes Institute, Shanghai Jiao Tong University Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"International Diabetes Federation. 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