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Gastroenterol."},{"key":"10.1002\/iub.1674-BIB0081|iub1674-cit-0081","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nature08991","article-title":"Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK\/SIRT1","volume":"464","author":"Iwabu","year":"2010","journal-title":"Nature"},{"key":"10.1002\/iub.1674-BIB0082|iub1674-cit-0082","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1210\/er.2011-1015","article-title":"The role of adiponectin in cancer: a review of current evidence","volume":"33","author":"Dalamaga","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1002\/iub.1674-BIB0083|iub1674-cit-0083","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ncponc0062","article-title":"Therapy insight: influence of type 2 diabetes on the development, treatment and outcomes of cancer","volume":"2","author":"Richardson","year":"2005","journal-title":"Nat. Clin. Pract. 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Metab."},{"key":"10.1002\/iub.1674-BIB0102|iub1674-cit-0102","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.4161\/auto.5.8.9991","article-title":"Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice","volume":"5","author":"Baerga","year":"2009","journal-title":"Autophagy"},{"key":"10.1002\/iub.1674-BIB0103|iub1674-cit-0103","first-page":"3329","article-title":"Autophagy regulates adipose mass and differentiation in mice","volume":"119","author":"Singh","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1002\/iub.1674-BIB0104|iub1674-cit-0104","doi-asserted-by":"crossref","first-page":"19860","DOI":"10.1073\/pnas.0906048106","article-title":"Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. 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Psychol."},{"key":"10.1002\/iub.1674-BIB0108|iub1674-cit-0108","first-page":"4493","article-title":"Cancer anorexia-cachexia syndrome: are neuropeptides the key?","volume":"59","author":"Inui","year":"1999","journal-title":"Cancer Res."},{"key":"10.1002\/iub.1674-BIB0109|iub1674-cit-0109","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3322\/canjclin.52.2.72","article-title":"Cancer anorexia-cachexia syndrome: current issues in research and management","volume":"52","author":"Inui","year":"2002","journal-title":"CA Cancer J. Clin."},{"key":"10.1002\/iub.1674-BIB0110|iub1674-cit-0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","article-title":"Cancer cachexia, mechanism and treatment","volume":"7","author":"Aoyagi","year":"2015","journal-title":"World J. Gastrointest. 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