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The aim of this study was to examine the association between <jats:italic>MMP1\u2010<\/jats:italic>1607dupG (rs1799750) and <jats:italic>MMP3<\/jats:italic>\u20101171dupA (rs3025058) gene polymorphisms and acute coronary syndromes (ACS) in the form of unstable angina. This study included 197 patients with ACS in the form of unstable angina confirmed by coronary angiography (defined by &gt;70% stenosis in at least one major coronary artery) and 144 healthy controls. There was no statistically significant difference in the distribution of the <jats:italic>MMP1\u2010<\/jats:italic>1607dupG (rs1799750) polymorphism between patients with unstable angina and the control group. With regard to the <jats:italic>MMP3<\/jats:italic>\u20101171dupA (rs3025058) polymorphism, a significant increase in the frequency of the 6A\/6A genotype among patients with unstable angina was detected. This association was confirmed in multivariate logistic regression analysis, where male sex and rs3025058 6A\/6A genotype were significantly associated with an increased risk of ACS. \u00a9 2017 IUBMB Life, 69(11):850\u2013855, 2017<\/jats:p>","DOI":"10.1002\/iub.1684","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T19:59:36Z","timestamp":1508183976000},"page":"850-855","source":"Crossref","is-referenced-by-count":5,"title":["<i>MMP1<\/i> and <i>MMP3<\/i> gene polymorphisms in patients with acute coronary syndromes"],"prefix":"10.1002","volume":"69","author":[{"given":"Andrzej","family":"Pawlik","sequence":"first","affiliation":[{"name":"Department of Physiology Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzenna","family":"Plucinska","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Nowa Sol Nowa Sol Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miko\u0142aj","family":"Kopec","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"G\u0142abowski","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-0659","authenticated-orcid":false,"given":"Micha\u0142","family":"Czerewaty","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Safranow","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0672-z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.306458"},{"key":"e_1_2_6_4_1","first-page":"151","article-title":"Activation mechanisms of matrix metalloproteinases","volume":"378","author":"Nagase H.","year":"1997","journal-title":"Biol. 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