{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:22:59Z","timestamp":1790396579629,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN\u2010143202"],"award-info":[{"award-number":["FDN\u2010143202"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Innate immunity relies on the effective recognition and elimination of pathogenic microorganisms. This entails sequestration of pathogens into phagosomes that promptly acquire microbicidal and degradative properties. This complex series of events, which involve cytoskeletal reorganization, membrane remodeling and the activation of multiple enzymes, is orchestrated by lipid signaling. To overcome this immune response, intracellular pathogens acquired mechanisms to subvert phosphoinositide\u2010mediated signaling and use host lipids, notably cholesterol, as nutrients. We present brief overviews of the role of phosphoinositides in phagosome formation and maturation as well as of cholesterol handling by host cells, and selected\n                    <jats:italic>Salmonella, Shigella, Chlamydia<\/jats:italic>\n                    and\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    to exemplify the mechanisms whereby intracellular pathogens co\u2010opt lipid metabolism in host cells. \u00a9 2018 IUBMB Life, 70(5):384\u2013392, 2018\n                  <\/jats:p>","DOI":"10.1002\/iub.1737","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T22:34:45Z","timestamp":1521844485000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The role of lipids in host\u2013pathogen interactions"],"prefix":"10.1002","volume":"70","author":[{"given":"Glenn F. 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