{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:55:55Z","timestamp":1783976155852,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:00:00Z","timestamp":1541808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to detect the circulating oxidized low\u2010density lipoprotein (ox\u2010LDL) levels of controls and patients with stable angina pectoris (SAP), unstable angina pectoris (UAP), and acute myocardial infarction (AMI) and also to investigate the correlation with the severity of coronary heart disease (CHD). Plasma levels of circulating ox\u2010LDL\u20104E6, malondialdehyde (MDA), high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), total cholesterol, high\u2010density lipoprotein cholesterol, LDL cholesterol, apoprotein A, apoprotein B, and lipoprotein (a) (Lp(a)) were measured in 99 participants who underwent coronary angiography. The plasma ox\u2010LDL level was significantly higher in patients with CHD than in controls (<jats:italic>P<\/jats:italic> = 0.000). However, it was lower in the UAP and AMI groups than in the SAP group (<jats:italic>P<\/jats:italic> = 0.000). The lipid peroxide level (MDA) showed a significant difference among all groups (<jats:italic>P<\/jats:italic> = 0.000). It increased significantly in patients with CHD. The Lp(a) and hs\u2010CRP levels were significantly higher in patients with CHD (<jats:italic>P<\/jats:italic> = 0.000 and 0.000, respectively). No difference in Lp(a) was found among the SAP, UAP, and AMI groups (<jats:italic>P<\/jats:italic> = 0.296). In patients with CHD, the plasma ox\u2010LDL correlated negatively with hs\u2010CRP (<jats:italic>P<\/jats:italic> = 0.011), and serum MDA correlated positively with hs\u2010CRP (<jats:italic>P<\/jats:italic> = 0.004). The plasma ox\u2010LDL could be used as a strong risk factor for the early stage but not the advanced stage of CHD. Hs\u2010CRP may bound and transfer ox\u2010LDL to macrophages. \u00a9 2018 IUBMB Life, 71(1):277\u2013282, 2019<\/jats:p>","DOI":"10.1002\/iub.1966","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T16:49:54Z","timestamp":1541868594000},"page":"277-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Circulating Oxidized Low\u2010Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease"],"prefix":"10.1002","volume":"71","author":[{"given":"Qiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Second Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshun","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-721X","authenticated-orcid":false,"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Second Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666131227162950"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7920-4_9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.11-00020R1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.03.047"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Oxidized low\u2010density lipoprotein as a biomarker of cardiovascular diseases","volume":"52","author":"Trpkovic A.","year":"2014","journal-title":"Crit. 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