{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:03:52Z","timestamp":1784905432827,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570684"],"award-info":[{"award-number":["81570684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bladder outlet obstruction is a common disease, which always evokes urinary bladder wall remodeling significantly. It has been suggested that bladder outlet obstruction can make the bladder progression from inflammation to fibrosis, and hypoxia may play a vital role. It has been found the expression of microRNA\u2010101 varied in bladder after BOO. But what role microRNA\u2010101 and hypoxia play in bladder is not well known. This study is to investigate the mechanism of microRNA\u2010101 and hypoxia in fibrosis of bladder after BOO. We found the expression of microRNA\u2010101 and hif\u20101\u03b1 increased in bladder after BOO. Hypoxia could promote the expression of extracellular matrix subtypes and microRNA\u2010101 in BSMCs. When microRNA\u2010101b was translated into BSMCs, the smad2\/3 signaling pathway was found to repress. Dual luciferase reporter detected that microRNA\u2010101b attenuated the TGF\u2010\u03b2 signaling pathway by inhibiting the expression of TGF\u03b2R1. Then, we conclude microRNA\u2010101b is induced by hypoxia and represses fibrosis of BSMCs by inhibiting the expression of TGF\u03b2R1 through TGF\u2010\u03b2 signaling pathway, and it may be an anti\u2010fibrotic miRNA for therapy. \u00a9 2018 IUBMB Life, 71(1):235\u2013243, 2019<\/jats:p>","DOI":"10.1002\/iub.1968","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T07:00:45Z","timestamp":1544770845000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["MicroRNA\u2010101 protects bladder of BOO from hypoxia\u2010induced fibrosis by attenuating TGF\u2010\u03b2\u2010smad2\/3 signaling"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-7117","authenticated-orcid":false,"given":"Ning","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University 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