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This process may be repressed by RING finger protein 10 (RNF10) in metabolic syndrome (MetS) rats. The aim of this study is to evaluate the inhibitory effects and molecular mechanisms of RNF10 on VSMC hyperproliferation. Neointimal hyperplasia in MetS and high\u2010glucose\u2010induced VSMC hyperproliferation were measured after infection with adenoviruses encoding RNF10 (Ad\u2010RNF10), short hairpin RNF10 (Ad\u2010shRNF10), or green fluorescent protein (Ad\u2010GFP). In vivo and in vitro<jats:italic>,<\/jats:italic> we found that overexpression of RNF10 significantly affected neointima formation and VSMC proliferation, and displayed further inhibitory activity by promoting mesenchyme homeobox 2 (Meox2) and suppressing activating protein 1 (AP\u20101). In contrast, Ad\u2010shRNF10 had an opposite effect on neointimal hyperplasia and VSMC hyperproliferation in vivo and in vitro. Our study indicated that RNF10 inhibited the hyperproliferation with the activities of Meox2 and AP\u20101 proteins. RNF10 may be a next drug target for treating vascular restenosis and other related cardiovascular diseases. \u00a9 2018 IUBMB Life, 71(5):632\u2013642, 2019<\/jats:p>","DOI":"10.1002\/iub.1995","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:58:07Z","timestamp":1546297087000},"page":"632-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["RING finger protein 10 attenuates vascular restenosis by inhibiting vascular smooth muscle cell hyperproliferation in vivo and vitro"],"prefix":"10.1002","volume":"71","author":[{"given":"Siyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiquan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology First 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