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As a bis\u2010thionohydrazide, elesclomol chelates with copper to form a copper complex in situ that via redox cycling of the metal ion greatly enhances oxidative stress in tumour cells. Here, we demonstrate that elesclomol is relatively potent against <jats:italic>Mtb<\/jats:italic> H37Rv with minimum inhibitory concentration of 10 \u03bcM (4 mg\/L) and against multidrug resistant clinical isolates of <jats:italic>Mtb<\/jats:italic>, displays additive interactions with known tuberculosis drugs such as isoniazid and ethambutol, and a synergistic interaction with rifampicin. Controlled supplementation of elesclomol with copper in culture medium increased <jats:italic>Mtb<\/jats:italic> sensitivity by &gt;65 fold. Overall, the activities of elesclomol in principle indicate the possibility of repurposing elesclomol or designing new thionohydrazides as potential drugs for use against <jats:italic>Mtb<\/jats:italic>. \u00a9 2019 IUBMB Life, 71(5):532\u2013538, 2019<\/jats:p>","DOI":"10.1002\/iub.2002","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T13:37:00Z","timestamp":1548855420000},"page":"532-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The evaluation of the anti\u2010cancer drug elesclomol that forms a redox\u2010active copper chelate as a potential anti\u2010tubercular drug"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6549-7789","authenticated-orcid":false,"given":"Andile H.","family":"Ngwane","sequence":"first","affiliation":[{"name":"DST\u2010NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray\u2010Dean","family":"Petersen","sequence":"additional","affiliation":[{"name":"DST\u2010NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bienyameen","family":"Baker","sequence":"additional","affiliation":[{"name":"DST\u2010NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-7930","authenticated-orcid":false,"given":"Ian","family":"Wiid","sequence":"additional","affiliation":[{"name":"DST\u2010NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Ning","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Haynes","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO. 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