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In the present study, we investigated the involvement of the glucagon\u2010like peptide 1 (GLP\u20101) receptor on human fibroblast\u2010like synoviocytes (FLS) in the pathogenesis of RA using the selective GLP\u20101 agonist exenatide, a licensed drug used for the treatment of type 2 diabetes. Our results indicate that exenatide may play a role in regulating tumor necrosis factor\u2010\u03b1\u2010induced mitochondrial dysfunction by increasing mitochondrial membrane potential, oxidative stress by reducing the production of reactive oxygen species, the expression of NADPH oxidase 4, expression of matrix metalloproteinase (MMP)\u20103 and MMP\u201013, release of proinflammatory cytokines including interleukin\u20101\u03b2 (IL\u20101\u03b2), IL\u20106, monocyte chemoattractant protein\u20101, and high\u2010mobility group protein 1, as well as activation of the p38\/nuclear factor of \u03ba light polypeptide gene enhancer in B\u2010cells inhibitor, \u03b1\/nuclear factor \u03baB signaling pathway in primary human RA FLS. These positive results indicate that exenatide may have potential as a therapeutic agent for the treatment and prevention of RA. \u00a9 2019 IUBMB Life, 9999(9999):1\u20139, 2019<\/jats:p>","DOI":"10.1002\/iub.2031","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T15:30:21Z","timestamp":1553182221000},"page":"969-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Exenatide ameliorates inflammatory response in human rheumatoid arthritis fibroblast\u2010like synoviocytes"],"prefix":"10.1002","volume":"71","author":[{"given":"Yunxia","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoran","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jining","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-2535","authenticated-orcid":false,"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.69"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.490"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken086"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20059"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2017.00507.8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02118"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10697"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.02.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204543"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29035"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1447"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel149"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S130834"},{"key":"e_1_2_8_17_1","first-page":"4349","article-title":"Exenatide reduces oxidative stress and cell death in testis in iron overload rat model","volume":"16","author":"Yesil S.","year":"2018","journal-title":"Exp. 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