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Making the state of play more intricate than initially envisioned, the synaptic vesicles of nerve terminals innervating the medulla contain various compounds, including various neurotransmitters and neuropeptides. Under basal conditions associated with a low splanchnic nerve discharge rate, neurotransmission is ensured by the synaptic release of the primary neurotransmitter acetylcholine (ACh). Under sustained and repetitive stimulations of the splanchnic nerve, as triggered in response to stressors, the synaptic release of neuropeptides, such as the pituitary adenylate cyclase\u2010activating polypeptide PACAP, supplants ACh release. The anatomical and functional changes that occur presynaptically at the preganglionic splanchnic nerve, combined with changes occurring postsynaptically at nicotinic acetylcholine receptors (nAChRs), confer the adrenomedullary synapses a solid and persistent aptitude to functional remodeling, from birth to aging. The present review focuses on the composite cholinergic and noncholinergic nature of neurotransmission occurring at the splanchnic nerve\u2010chromaffin cell synapse and its remodeling in response to physiological or pathological stimuli.<\/jats:p>","DOI":"10.1002\/iub.2117","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T15:30:02Z","timestamp":1563031802000},"page":"553-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Cholinergic and peptidergic neurotransmission in the adrenal medulla: A dynamic control of stimulus\u2010secretion coupling"],"prefix":"10.1002","volume":"72","author":[{"given":"Nathalie C.","family":"Gu\u00e9rineau","sequence":"first","affiliation":[{"name":"IGF Univ. 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