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Considering the role of LRP1 in lipid metabolism, we investigated the effect of PID1 on the content and biological activities of serum lipoproteins in pigs. PID1\u2010transgenic pigs were genetated by sperm and magnetic nanoparticles\u2010mediated method. The levels of PID1 in PID1\u2010transgenic pig's liver were higher than that in the wild\u2010type pig's liver. We found that serum levels of high\u2010density lipoprotein cholesterol (HDL\u2010C) and apolipoprotein A\u2010I (apoA\u2010I) were significantly reduced in PID1\u2010transgenic pigs. On the other hand, PID1\u2010transgenic pigs displayed increased non\u2010HDL\u2010C levels. Serum levels of total cholesterol and triglycerides were comparable between the PID1\u2010transgenic and the wild\u2010type pigs. Further, the HDL isolated from PID1\u2010transgenic pigs showed a significant reduction in cholesterol efflux ability. In addition, serum superoxide dismutase activity of PID1\u2010transgenic pigs was also obviously lowered compared with that of wild type pigs. In conclusion, these results suggest that PID1 might be able to adjust HDL\u2010C levels in serum and HDL cholesterol efflux ability.<\/jats:p>","DOI":"10.1002\/iub.2135","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T15:04:10Z","timestamp":1563980650000},"page":"1946-1951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Overexpression of PID1 reduces high density lipoprotein level and functionality in swine"],"prefix":"10.1002","volume":"71","author":[{"given":"Qingjie","family":"Mu","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Weifang Medical University  Weifang Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shandong Laboratory Animal Center of Shandong Academy of Medical Science  Jinan Shandong People's Republic of 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