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It causes a quick rise in body temperature to highly irreversible levels, which causes death in around three of four cases. The trigger anesthetics cause an anomalous, continued ascent in myoplasmic calcium levels. Possible mechanisms by which continuous release of sodium, calcium from skeletal muscle plasma membrane and sarcoplasmic reticulum stores respectively can produce the profound hyperthermia are discussed.<\/jats:p>","DOI":"10.1002\/iub.2138","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T16:00:15Z","timestamp":1565020815000},"page":"2048-2054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overactivation of the sodium\u2013calcium exchanger and transient receptor potential in anesthesia\u2010induced malignant hyperthermia"],"prefix":"10.1002","volume":"71","author":[{"given":"Peng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The Second Hospital of Jilin University  Changchun Jilin 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