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LPA mediates a wide range of biological effects in many tissue types that have been recently reviewed; however, its effects on vasculature development and function have received comparatively less examination. In this review, literature on the actions of LPA in three main aspects of vascular development (vasculogenesis, angiogenesis, and vascular maturation) is discussed. In addition, evidence for the roles of LPA signaling in the formation of secondary vascular structures, such as the blood brain barrier, is considered, consistent with significant roles for LPA signaling in vascular development, function, and disease. \u00a9 2009 IUBMB IUBMB Life, 61(8): 791\u2013799, 2009<\/jats:p>","DOI":"10.1002\/iub.220","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T16:34:29Z","timestamp":1248194069000},"page":"791-799","source":"Crossref","is-referenced-by-count":58,"title":["Lysophosphatidic acid in vascular development and disease"],"prefix":"10.1002","volume":"61","author":[{"given":"Siew T.","family":"Teo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun C.","family":"Yung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deron 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