{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:36:10Z","timestamp":1761060970887,"version":"3.43.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803850"],"award-info":[{"award-number":["81803850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intestinal ischemia\u2013reperfusion injury (IIR) is a life\u2010threatening abdominal emergency. Compared to traditional steady\u2010state works, we profiled the blood of rats over 72\u2009hr (15 time points) and examined dynamic changes in molecular pathways during IIR. Using a series of methods designed for dynamic datasets analysis (batch effects corrections, metabolomics data reduction, and different features selection), we identified 39 significant different metabolites and discovered the trends of these molecules. Four main patterns were uncovered by a longitudinal pattern recognition method. Furthermore, pathway networks were explored to uncover the possible mechanisms of IIR. We found that IIR is a complex physiological process involved in multiple pathways, such as biosynthesis of amino acids, 2\u2010oxocarboxylic acid metabolism, arginine\u2010related metabolism, and glutathione metabolism. Among which, metabolites related with phenylalanine tyrosine and tryptophan metabolism reached a peak during the early stage of reperfusion, while molecules in biosynthesis of unsaturated fatty acids metabolism declined. Our work provides a feasible scheme to understand dynamic molecule variation and will provide new explications about the effect of intestinal ischemia reperfusion from a dynamic perspective.<\/jats:p>","DOI":"10.1002\/iub.2238","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T08:40:24Z","timestamp":1580373624000},"page":"1001-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic metabolomic analysis of intestinal ischemia\u2013reperfusion injury in rats"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-8046","authenticated-orcid":false,"given":"Die","family":"Dai","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular\u2010Imaging, Department of Bioinformatics and Systems Biology College of Life Science and Technology, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingchao","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular\u2010Imaging, Department of Bioinformatics and Systems Biology College of Life Science and Technology, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglu","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Life Science, Henan Normal University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zunjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance Ministry of Education, China Pharmaceutical University  Nanjing China"},{"name":"Jiangsu Key Laboratory of Drug 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