{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:04Z","timestamp":1747149304819,"version":"3.40.5"},"reference-count":68,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study purposed to examine the prospective curative role of lipoxin A<jats:sub>4<\/jats:sub> (LXA<jats:sub>4<\/jats:sub>) in induced gastric ulcer in rats and explore the possible involvement of mitochondrial dynamics signaling pathway. Forty\u2010eight male Wistar rats were divided into four groups: control, indomethacin (IND), IND\u2009+\u2009omeprazole (IND\u2009+\u2009Omez), and IND+ LXA<jats:sub>4<\/jats:sub> groups. At the end of the experiment, the gastric pH, gastric fluid volume, total gastric acidity, ulcer index, and curative index were estimated. The gene expression of mitochondrial related protein 1 and mitofusin 2 were determined. In addition, some mitochondrial parameters include mitochondrial transmembrane potential, complex\u2010I activity and reactive oxygen species were measured. Also, some gastric biochemical parameters, histopathological, and immunohistochemical analyses of the gastric mucosa were determined. We found that IND induced gastric ulcer, as manifested by the biochemical, histopathological, and immunohistochemical analyses. Both Omez and LXA<jats:sub>4<\/jats:sub> treatment for 15\u2009days alleviated the IND\u2010induced gastric ulcer as explored by ameliorating the biochemical, histopathological, and immunohistochemical findings. We concluded that LXA<jats:sub>4<\/jats:sub> mitigated the IND\u2010induced gastric ulcer via improving the mitochondrial dynamic imbalance and mitochondrial dysfunction, in addition to its anti\u2010apoptotic, anti\u2010inflammatory, and antioxidant properties.<\/jats:p>","DOI":"10.1002\/iub.2260","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T13:08:22Z","timestamp":1582895302000},"page":"1379-1392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The prospective curative role of lipoxin A<sub>4<\/sub> in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway"],"prefix":"10.1002","volume":"72","author":[{"given":"Nermin M.","family":"Madi","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowida R.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada M.","family":"Alghazaly","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karima E.","family":"Marea","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-2799","authenticated-orcid":false,"given":"Mervat H.","family":"El\u2010Saka","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2141-9248.126604"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i38.5404"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6703296"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0306"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S71976"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207449"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180629111227"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.10-79"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004415"},{"issue":"6","key":"e_1_2_8_11_1","first-page":"1","article-title":"Mechanisms of mitochondrial fission and fusion","volume":"5","author":"Bliek AM","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"1","article-title":"Reactive oxygen species and mitochondrial dynamics: The Yin and Yang of mitochondrial dysfunction and cancer progression","volume":"7","author":"Jezek J","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-018-0665-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.05.034"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2017.1417631"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/693567"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020179"},{"key":"e_1_2_8_18_1","first-page":"181","article-title":"Lipoxins: Nature's way to resolve inflammation","volume":"8","author":"Chandrasekharan JA","year":"2015","journal-title":"J Inflamm Res"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00318"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10441-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-13-30"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.05.013"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9303606"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051265"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.91582"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0442"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.969"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/796405"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2013.06.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2040731"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805329200"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90661-0"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.119750"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703055"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00403A"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510977103"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy335"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.10-133"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2010.00645.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813832-8.00007-8"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089742"},{"issue":"5","key":"e_1_2_8_45_1","first-page":"5","article-title":"Prostaglandins and ulcer healing","volume":"56","author":"Konturek SJ","year":"2005","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3431"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2016.00029"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.092"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602023113"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111618"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12361"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.10.016"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.07.014"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600647R"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856005774649331"},{"issue":"1","key":"e_1_2_8_56_1","first-page":"I319","article-title":"Elevated endothelin\u20101 levels impair nitric oxide homeostasis through a PKC\u2010dependent pathway","volume":"114","author":"Ramzy D","year":"2006","journal-title":"Circulation"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479536"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.64723"},{"issue":"2","key":"e_1_2_8_59_1","article-title":"Myeloperoxidase as an active disease biomarker: Recent biochemical and pathological perspectives","volume":"6","author":"Khan AA","year":"2018","journal-title":"Med Sci (Basel)"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201951"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2012.16.6.399"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1601OC"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.15-124"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.18468"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.03.029"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_49_17"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371490"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5470457"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.343"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.2260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.2260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iub.2260","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.2260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:31:11Z","timestamp":1694003471000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.2260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":68,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/iub.2260"],"URL":"https:\/\/doi.org\/10.1002\/iub.2260","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"type":"print","value":"1521-6543"},{"type":"electronic","value":"1521-6551"}],"subject":[],"published":{"date-parts":[[2020,2,27]]},"assertion":[{"value":"2019-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}