{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:43:45Z","timestamp":1791974625448,"version":"4.4.0"},"reference-count":92,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Copper (Cu) is an essential micronutrient involved in a variety of fundamental biological processes. Recently, disorder of Cu homeostasis can be observed in many malignancies. Elevated Cu levels in serum and tissue are correlated with cancer progression. Hence, targeting Cu has emerged as a novel strategy in cancer treatment. This review provides an overview of physiological Cu metabolism and its homeostasis, followed by a discussion of the dysregulation of Cu homeostasis in cancer and the effects of Cu on cancer progression. Finally, recent therapeutic advances using Cu coordination complexes as anticancer agents, as well as the mechanisms of their anti\u2010cancer action are discussed. This review contributes full comprehension to the role of Cu in cancer and demonstrates the broad application prospect of Cu coordination compounds as potential therapeutic agents.<\/jats:p>","DOI":"10.1002\/iub.2341","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T21:10:10Z","timestamp":1593465010000},"page":"1900-1908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":270,"title":["Copper homeostasis: Emerging target for cancer treatment"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-9725","authenticated-orcid":false,"given":"Yueqin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine Xiangya Hospital, Central South University  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1355-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MT00219C"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.349.6244.129"},{"key":"e_1_2_9_5_1","first-page":"303","article-title":"Copper depletion as a therapeutic strategy in cancer","volume":"19","author":"Lopez J","year":"2019","journal-title":"Metal Ions Life Sci"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00202A"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MT00149H"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.07.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.01.011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1437"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-012-9528-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.26286"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.20.1.291"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-030409-143539"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.05.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9045-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0163"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0018-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7500-8_11"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.06.018"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"BC25","article-title":"Serum levels of metal ions in female patients with breast cancer","volume":"9","author":"Pavithra V","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180161"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00742.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518798507"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i4.612"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9682-z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0304-9"},{"issue":"5","key":"e_1_2_9_29_1","first-page":"331","article-title":"Serum levels of ferritin, copper, and zinc in patients with oral cancer","volume":"37","author":"Baharvand M","year":"2014","journal-title":"Biom J"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.282"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160405111543"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.07.009"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2014.11"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040871"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13180"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2559"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.10.009"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.194662"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00359-9"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7018"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00105J"},{"key":"e_1_2_9_42_1","first-page":"469","article-title":"Copper complexes in cancer therapy","volume":"18","author":"Denoyer D","year":"2018","journal-title":"Metal Ions Life Sci"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00132.2018"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910722117"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-019-01044-4"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-3152"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27320"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14492"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu072"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004870"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124865"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.40"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.08.080"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318431110"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.10.020"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12568"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.03.042"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.05.023"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20174"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2019.06.008"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787846622"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-012-0105-z"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817473116"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.05.027"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.7.781"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200104000-00024"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.neo.7900218"},{"issue":"7","key":"e_1_2_9_68_1","first-page":"617","article-title":"Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma","volume":"2","author":"Pan Q","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.neo.7900258"},{"issue":"1","key":"e_1_2_9_70_1","first-page":"1","article-title":"Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study","volume":"6","author":"Brewer GJ","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14296"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179907"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1190"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3705"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050659"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1784"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073684"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.06.026"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X17731520"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10740"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1537"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.6022"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400198p"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110123"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574892814666190514104035"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1722"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091080"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.07.030"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0864"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2017.04.022"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.04.011"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12992"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.03.006"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.2341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.2341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iub.2341","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.2341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:47:17Z","timestamp":1693885637000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.2341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,29]]},"references-count":92,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/iub.2341"],"URL":"https:\/\/doi.org\/10.1002\/iub.2341","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,29]]},"assertion":[{"value":"2020-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}