{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:13:52Z","timestamp":1787498032393,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cisplatin (CP), as a chemotherapeutic drug, causes nephrotoxicity that has limited the clinical utility of CP. Gliclazide (GLZ), as an antihyperglycemic drug, at low dose has antioxidant property. In this study, we aimed to investigate the protective effect of GLZ against CP\u2010induced acute renal injury. Sixty\u2010four BALB\/c mice were randomly divided into eight groups. The groups were included as control, GLZ (5, 10, and 25\u2009mg\/kg), CP, and GLZ (5, 10, and 25\u2009mg\/kg)\u2009+\u2009CP. Renal function markers (serum creatinine and blood urea nitrogen), oxidative stress markers (malondialdehyde and glutathione), apoptotic marker (caspase\u20103), and NF\u2010\u03baB were histopathologically evaluated. The results of our study showed that increased urea and creatinine were evidence of CP\u2010induced nephrotoxicity. Histopathological examination revealed tubular epithelial and Bowman degeneration, edema, and cytoplasmic vacuolation in renal tissue structure. Administration of GLZ reduced oxidative stress, caspase\u20103, and NF\u2010\u03baB activity, and improved kidney function markers in CP\u2010treated mice compared with CP alone group. Also, we observed that the histological tissue structure of the kidney was maintained. GLZ at dose of 25\u2009mg\/kg had higher protective effect as compared with other doses. Overall, our study suggests that GLZ with antioxidant, antiapoptotic, and anti\u2010inflammatory properties may be a promising new therapeutic agent to prevent CP\u2010induced nephrotoxicity.<\/jats:p>","DOI":"10.1002\/iub.2342","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T16:16:10Z","timestamp":1595261770000},"page":"2024-2033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Gliclazide attenuates cisplatin\u2010induced nephrotoxicity through inhibiting\n                    <scp>NF\u2010\u03baB<\/scp>\n                    and caspase\u20103 activity"],"prefix":"10.1002","volume":"72","author":[{"given":"Fatemeh","family":"Taghizadeh","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Student Research Committee, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Jalal","family":"Hosseinimehr","sequence":"additional","affiliation":[{"name":"Department of Radiopharmacy, Faculty of Pharmacy Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehryar","family":"Zargari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbasali","family":"Karimpour Malekshah","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-7439","authenticated-orcid":false,"given":"Fereshteh Beigom","family":"Talebpour Amiri","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0392-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1502"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"890","article-title":"Licorice and its active compound glycyrrhizic acid ameliorates cisplatin\u2010induced nephrotoxicity through inactivation of p53 by scavenging ROS and overexpression of p21 in human renal proximal tubular epithelial cells","volume":"21","author":"Ju S","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152862"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1457-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.05.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2018.1420926"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/07435800500371805"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/230342"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2006.07.006"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"1509","article-title":"miRNA\u2010mRNA regulatory network analysis of mesenchymal stem cell treatment in cisplatin\u2010induced acute kidney injury identifies roles for miR\u2010210\/Serpine1 and miR\u2010378\/Fos in regulating inflammation","volume":"20","author":"Zhang C","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1323-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.114919"},{"issue":"3","key":"e_1_2_8_15_1","first-page":"e63293","article-title":"Zataria multiflora alleviates cisplatin\u2010induced oxidative stress, apoptosis, and nephrotoxicity in mice","volume":"14","author":"Karimi S","year":"2019","journal-title":"Jundishapur J Nat Pharm Prod"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.12991\/mpj.2018.55"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.15171\/jnp.2017.13"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2017.06.052"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9tx00141g"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-01683-w"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-3162-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.04.031"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_202_17"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(00)00084-2"},{"issue":"11","key":"e_1_2_8_25_1","first-page":"14","article-title":"Comparative characteristics of antioxidant properties of hypoglycemic agents diabenol and gliclazide","volume":"74","author":"Spasov A","year":"2011","journal-title":"Eksp Klin Farmakol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.04.019"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.02.042"},{"issue":"7","key":"e_1_2_8_28_1","first-page":"689","article-title":"Expression profile of markers of oxidative stress, injury and apoptosis in anti\u2010tuberculosis drugs induced nephrotoxicity","volume":"24","author":"Sharma R","year":"2019","journal-title":"Nephrol Ther"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00470.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.680"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.03.017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283512c00"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.11.007"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","unstructured":"SenaCM LouroT MatafomeP NunesE MonteiroP Sei\u00e7aR.Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high\u2010fat diet.2009 2009;58(2):203\u2013209.","DOI":"10.33549\/physiolres.931480"},{"issue":"3","key":"e_1_2_8_35_1","first-page":"187","article-title":"Biochemical and Histopathological investigation of resveratrol, Gliclazide, and losartan protective effects on renal damage in a diabetic rat model","volume":"37","author":"Ezel T","year":"2015","journal-title":"Anal Quant Cytopathol Histopathol"},{"issue":"1","key":"e_1_2_8_36_1","first-page":"1","article-title":"Metformin protects against cisplatin\u2010induced tubular cell apoptosis and acute kidney injury via AMPK\u03b1\u2010regulated autophagy induction","volume":"6","author":"Li J","year":"2016","journal-title":"Sci Rep"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.06.038"},{"issue":"3","key":"e_1_2_8_38_1","first-page":"347","article-title":"Effect of gliclazide on nucleotide excision repair (NER) and non\u2010homologous DNA end joining (NHEJ) in normal and cancer cells","volume":"61","author":"Sliwinska A","year":"2010","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105070"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.06.020"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(00)00082-9"}],"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiub.2342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.2342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iub.2342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iub.2342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:48:34Z","timestamp":1693871314000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/iub.2342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/iub.2342"],"URL":"https:\/\/doi.org\/10.1002\/iub.2342","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]},"assertion":[{"value":"2020-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}