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Efforts made to develop antiviral strategies for the treatment of COVID\u201019 are underway. Respiratory viral infections, such as influenza, predispose patients to co\u2010infections and these lead to increased disease severity and mortality. Numerous types of antibiotics such as azithromycin have been employed for the prevention and treatment of bacterial co\u2010infection and secondary bacterial infections in patients with a viral respiratory infection (e.g., SARS\u2010CoV\u20102). Although antibiotics do not directly affect SARS\u2010CoV\u20102, viral respiratory infections often result in bacterial pneumonia. It is possible that some patients die from bacterial co\u2010infection rather than virus itself. To date, a considerable number of bacterial strains have been resistant to various antibiotics such as azithromycin, and the overuse could render those or other antibiotics even less effective. Therefore, bacterial co\u2010infection and secondary bacterial infection are considered critical risk factors for the severity and mortality rates of COVID\u201019. Also, the antibiotic\u2010resistant as a result of overusing must be considered. In this review, we will summarize the bacterial co\u2010infection and secondary bacterial infection in some featured respiratory viral infections, especially COVID\u201019.<\/jats:p>","DOI":"10.1002\/iub.2356","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T16:36:24Z","timestamp":1596904584000},"page":"2097-2111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":260,"title":["Bacterial co\u2010infections with <scp>SARS\u2010CoV<\/scp>\u20102"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-6495","authenticated-orcid":false,"given":"Rasoul","family":"Mirzaei","sequence":"first","affiliation":[{"name":"Department of Microbiology School of Medicine, Hamadan University of Medical Sciences  Hamadan Iran"},{"name":"Student Research Committee Hamadan University of Medical Sciences  Hamadan 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