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In response to the SARS\u2010CoV\u20102 infection, the innate immune response is the first line of defense, triggering multiple signaling pathways to produce interferons, pro\u2010inflammatory cytokines and chemokines, and initiating the adaptive immune response against the virus. Unsurprisingly, the virus has developed strategies to evade detection, which can result in delayed, excessive activation of the innate immune system. The response elicited by the host depends on multiple factors, including health status, age, and sex. An overactive innate immune response can lead to a cytokine storm, inflammation, and vascular disruption, leading to the vast array of symptoms exhibited by COVID\u201019 patients. What is known about the expression and epigenetic regulation of the <jats:italic>ACE2<\/jats:italic> gene and the various players in the host response are explored in this review.<\/jats:p>","DOI":"10.1002\/iub.2379","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T22:19:06Z","timestamp":1600294746000},"page":"2331-2354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["<scp>SARS\u2010CoV<\/scp>\u20102 multifaceted interaction with the human host. 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