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TNF blocking reinforces the TB granuloma formation and maintenance and the growth of<jats:italic>Mycobacterium tuberculosis<\/jats:italic>(Mtb). After intercurrent of TB infection, the standard recommendation is that the treatment with TNF inhibitors to be withheld despite its impressive effect on suppression of inflammation until the infection has resolved. Knowing pathways and mechanisms that are common between two diseases might help to find the mechanistic basis of this comorbidity, as well as provide us a new approach to apply them as therapeutic targets or diagnostic biomarkers. Also, screening for latent TB before initiation of an anti\u2010TNF therapy can minimize complications. This review summarizes the shared gene signature between TB and RA and discusses the biomarkers for early detection of this infection, and screening procedures as well.<\/jats:p>","DOI":"10.1002\/iub.2413","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T08:29:48Z","timestamp":1605947388000},"page":"26-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-1185","authenticated-orcid":false,"given":"Parisa","family":"Zafari","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine Mazandaran University of Medical Sciences Sari Iran"},{"name":"Student Research Committee Mazandaran University of Medical Sciences Sari 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