{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:03:47Z","timestamp":1789243427551,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glioma alone accounts for 30% of various kinds of primary brain tumors and is the highest cause of mortality associated with intracranial malignant cancers. In the present study, Suzuki\u2010coupling products of remimazolan were synthesized and investigated for anti\u2010neoplastic property against glioma cells. RFMSP treatment for 48\u2009hr suppressed viabilities of U\u2010118MG and U87MG cells in dose dependent manner. Exposure of primary astrocytes to RFMSP at 2\u201320\u2009\u03bcM concentration range minimally affected viabilities. RFMSP treatment at 5 \u03bcM doses raised apoptotic cell count to 53.8\u2009\u00b1\u20092.3% and 48.2\u2009\u00b1\u20091.8%, respectively in U\u2010118MG and U87MG cells. Treatment of the cells with RFMSP induced nuclear condensation and subsequent fragmentation. In RFMSP treated U\u2010118MG and U87MG cells, NF\u2010\u03baB p65 expression was markedly suppressed compared to the control cells. Additionally, RFMSP treatment decreased the ratio of nuclear to total NF\u2010\u03baB p65 level in both the cell lines. Treatment of U\u2010118MG and U87MG cells with 5 \u03bcM RFMSP for 48\u2009hr caused a marked down\u2010regulation in survivin and XIAP levels. Treatment with RFMSP promoted Bax expression and suppressed Bcl\u20102 level. The caspase\u20109 and \u20103 activation was markedly induced by RFMSP treatment in U\u2010118MG and U87MG cells compared to the control cells. In summary, the RFMSP synthesized by Suzuki\u2010coupling of RFMSP inhibited glioma cell survival via DNA damage mediated apoptosis. The anti\u2010glioma potential of RFMSP involved down\u2010regulation of NF\u2010\u03baB expression, targeted survivin &amp; XIAP levels and induced caspase activation in glioma cells. Therefore, RFMSP may be studied further as therapeutic agent for the treatment of glioma.<\/jats:p>","DOI":"10.1002\/iub.2433","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:18:11Z","timestamp":1608887891000},"page":"341-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Remimazolan inhibits glioma cell growth and induces apoptosis through down\u2010regulation of <scp>NF\u2010\u03baB<\/scp> pathway"],"prefix":"10.1002","volume":"73","author":[{"given":"Wei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First People's Hospital of Jingzhou The First Affiliated Hospital of Yangtze University  Jingzhou Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The Third People's Hospital of Jingzhou  Jingzhou Hubei 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