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Immune checkpoint inhibitors (ICIs) are regarded as potential strategies in enhancing the immune responses in patients with cancer, particularly colorectal cancer (CRC). Notably, CRCs are extraordinarily heterogeneous and mostly are microsatellite\u2010stable (MSS) or cold tumors, which means that the immune response is not usually as strong as that of foreign cells. T\u2010cell immunoglobulin and ITIM domain (TIGIT) is a new immune checkpoint receptor overexpressed inside the CRC tumor\u2010immune microenvironments. Moreover, several studies have shown that TIGIT in combination with other ICIs and\/or conventional treatments, can lead to a robust anti\u2010tumor response in CRC. This review looks deep inside TIGIT expression patterns, their various functions, and possible immunotherapy strategies to increase survival rates and decrease immune\u2010related adverse events.<\/jats:p>","DOI":"10.1002\/iub.2461","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:19:55Z","timestamp":1615249195000},"page":"726-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["T\u2010cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-9830","authenticated-orcid":false,"given":"Mehrdad","family":"Fathi","sequence":"first","affiliation":[{"name":"Cancer and Immunology Research Center Kurdistan University of Medical Sciences  Sanandaj Iran"},{"name":"Department of Immunology, Faculty of Medicine Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Pustokhina","sequence":"additional","affiliation":[{"name":"Kazan Federal University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"I.M. 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