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Limited to the lack of diagnostic markers and effective drug targets, cardiac apoptosis is still a major clinical challenge. Here, we reveal a potential novel therapeutic target for cardiac apoptosis. In the cause of the study, we found that KLHL38 was highly expressed in cardiac tissue of HF patients via GEO data\u2010mining, which was further verified in the heart tissue of transverse aortic constriction mice. Meanwhile, the expression of KLHL38 is negatively correlated with myocardin protein level, which is a key cardiac apoptosis regulator. The KLHL38 overexpression obviously promoted cardiomyocyte apoptosis treated with staurosporine by facilitation of myocardin's ubiquitylation and subsequent proteasomal degradation. These findings reveal a new therapeutic target, which may provide a new theoretical foundation for the treatment of myocardial apoptosis in clinical practice.<\/jats:p>","DOI":"10.1002\/iub.2602","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T09:59:02Z","timestamp":1643882342000},"page":"446-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["KLHL38 facilitates staurosporine\u2010induced apoptosis in HL\u20101 cells via myocardin degradation"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-7641","authenticated-orcid":false,"given":"Ying","family":"Luo","sequence":"first","affiliation":[{"name":"College of Biological Science and Technology Hubei Minzu University Enshi Hubei China"},{"name":"Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic diseases Hubei Minzu University Enshi Hubei 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